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Tbio
RTCA
RNA 3'-terminal phosphate cyclase

Protein Summary
Description
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260563
  • ENSP00000260563
  • ENSG00000137996
  • ENST00000370128
  • ENSP00000359146

Symbol
  • RPC
  • RPC1
  • RTC1
  • RTCD1
  • RPC
  • RTC1
  • RTCD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.85
interacting protein
0.82
histone modification site profile
0.76
transcription factor binding site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.998211061
p_ni:  0.001663851
p_wrong:  0.000125087
Score:  0.177
Data Source:  BioPlex,STRINGDB
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.997311941
p_ni:  0.002213213
p_wrong:  0.000474846
Score:  0.245
Data Source:  BioPlex,STRINGDB
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.991021672
p_ni:  0.008972252
p_wrong:  0.000006076
Data Source:  BioPlex
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.980843104
p_ni:  0.017575338
p_wrong:  0.001581558
Score:  0.189
Data Source:  BioPlex,STRINGDB
RSAD1
Tdark
Novelty:  0.63344405
p_int:  0.958410319
p_ni:  0.041589681
Data Source:  BioPlex
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
p_int:  0.829257077
p_ni:  0.170436552
p_wrong:  0.000306371
Data Source:  BioPlex
BMS1
Tbio
Novelty:  0.0349992
Score:  0.969
Data Source:  STRINGDB
PNO1
Tbio
Novelty:  0.05311566
Score:  0.961
Data Source:  STRINGDB
BYSL
Tbio
Novelty:  0.01919968
Score:  0.952
Data Source:  STRINGDB
IMP4
Tdark
Novelty:  9.64444444
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
2
3
5.8
66.8
HbA1c measurement
1
1
1
35
serum urea measurement
1
1
1
33.1
creatinine measurement
1
1
1
5.1
myeloid white cell count
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
5.8
66.8
HbA1c measurement
1
35
serum urea measurement
1
33.1
creatinine measurement
1
5.1
myeloid white cell count
1
4.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA 3'-terminal phosphate cyclase
VGNC:8099
457057
Macaque
RNA 3'-terminal phosphate cyclase
711623
Mouse
MGI:1913618
66368
Rat
RGD:1303111
295395
Dog
RNA 3'-terminal phosphate cyclase
VGNC:54065
479928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA 3'-terminal phosphate cyclase
Macaque
RNA 3'-terminal phosphate cyclase
Mouse
Rat
Dog
RNA 3'-terminal phosphate cyclase
Publication Statistics
PubMed Score 31.43
PubMed score by year
PubTator Score 44.44
PubTator score by year
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Related Publications
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PMID
Year
Title