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Tbio
RSU1
Ras suppressor protein 1

Protein Summary
Description
Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro. This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345264
  • ENSP00000339521
  • ENSG00000148484
  • ENST00000377921
  • ENSP00000367154
  • ENST00000602389
  • ENSP00000473588

Symbol
  • RSP1
  • RSP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
virus perturbation
0.97
histone modification site profile
0.85
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.98   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.98   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
PARVA
Tbio
Novelty:  0.02736601
p_int:  1
Score:  0.934
Data Source:  BioPlex,STRINGDB
PARVB
Tbio
Novelty:  0.03825772
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.968
Data Source:  BioPlex,STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
p_int:  0.999999941
p_ni:  5.9e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
PARVG
Tbio
Novelty:  0.08921402
p_int:  0.999997561
p_ni:  0.000002439
Score:  0.902
Data Source:  BioPlex,STRINGDB
LIMS1
Tbio
Novelty:  0.00648304
p_int:  0.999986818
p_ni:  0.000013182
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
USP3
Tbio
Family:  Enzyme
Novelty:  0.02331328
Score:  0.832
Data Source:  STRINGDB
LIMS3
Tbio
Novelty:  0.14674425
Score:  0.821
Data Source:  STRINGDB
RSPH6A
Tdark
Novelty:  0.03734897
Score:  0.809
Data Source:  STRINGDB
LIMS2
Tbio
Novelty:  0.0832739
Score:  0.783
Data Source:  STRINGDB
RSPH3
Tdark
Novelty:  0.04470453
Score:  0.707
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
5
5
10
98.9
albuminuria
3
2
3
94.8
urinary microalbumin measurement
1
2
2
89.4
Moderate albuminuria
1
1
0
1.8
86.8
urate measurement
3
3
3
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
10
98.9
albuminuria
3
94.8
urinary microalbumin measurement
2
89.4
Moderate albuminuria
0
1.8
86.8
urate measurement
3
71.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras suppressor protein 1
VGNC:12485
738898
Macaque
Ras suppressor protein 1 [Source:HGNC Symbol;Acc:HGNC:10464]
Mouse
MGI:103040
20163
Rat
RGD:1591781
680419
Dog
Ras suppressor protein 1
VGNC:52921
477993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras suppressor protein 1
Macaque
Ras suppressor protein 1 [Source:HGNC Symbol;Acc:HGNC:10464]
Mouse
Rat
Dog
Ras suppressor protein 1
Publication Statistics
PubMed Score 66.98
PubMed score by year
PubTator Score 22.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title