Protein Summary
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805). This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repea ...more
- ENST00000356545
- ENSP00000348944
- ENSG00000169218
- ENST00000401068
- ENSP00000383846
- ENST00000612451
- ENSP00000479832
- ENST00000615459
- ENSP00000481178
- RSPO
- CRISTIN3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
tissue | 0.61 | ||
cell line | 0.6 | ||
gene perturbation | 0.6 | ||
cell type or tissue | 0.57 | ||
PubMedID | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 284.41 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 257 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 284.41 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 257 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (117)
LACRT
Novelty: 0.03333799
p_int: 0.925771551
p_ni: 0.069407102
p_wrong: 0.004821347
Data Source: BioPlex
CHTOP
Novelty: 0.04170391
p_int: 0.897010672
p_ni: 0.102989328
Score: 0.254
Data Source: BioPlex,STRINGDB
ZNF579
Family: TF
Novelty: 4.75515836
p_int: 0.877568616
p_ni: 0.122424754
p_wrong: 0.00000663
Score: 0.222
Data Source: BioPlex,STRINGDB
HECTD3
Family: Enzyme
Novelty: 2.20874654
p_int: 0.797678589
p_ni: 0.202321411
Score: 0.167
Data Source: BioPlex,STRINGDB
CEP76
Novelty: 0.3880387
p_int: 0.765755989
p_ni: 0.233593253
p_wrong: 0.000650758
Score: 0.226
Data Source: BioPlex,STRINGDB
ZZEF1
Novelty: 0.33216648
p_int: 0.759688525
p_ni: 0.240311463
p_wrong: 1.2e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (4)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Regulation of FZD by ubiquitination | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by WNT | ||||
Reactome | TCF dependent signaling in response to WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Regulation of FZD by ubiquitination | ||||
Signal Transduction | ||||
Signaling by WNT | ||||
TCF dependent signaling in response to WNT | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
corneal topography | 4 | 1 | 4 | 87.2 | |||||
intraocular pressure measurement | 4 | 4 | 5 | 71.3 | |||||
1 | 1 | 0 | 1.1 | 50.6 | |||||
body mass index | 1 | 1 | 1 | 40.7 | |||||
1 | 1 | 0 | 1.1 | 35 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
corneal topography | 4 | 87.2 | |||||
intraocular pressure measurement | 5 | 71.3 | |||||
0 | 1.1 | 50.6 | |||||
body mass index | 1 | 40.7 | |||||
0 | 1.1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | R-spondin 1 | VGNC:6988 | 469283 | |||||
Macaque | R-spondin 1 | 713976 | ||||||
Mouse | MGI:2183426 | 192199 | ||||||
Rat | RGD:1565558 | 313589 | ||||||
Dog | R-spondin 1 | VGNC:45782 | 608179 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | R-spondin 1 | |||||
Macaque | R-spondin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | R-spondin 1 | |||||
Publication Statistics
PubMed Score 284.41
PubMed score by year
PubTator Score 111.82
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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