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Tbio
RSPH9
Radial spoke head protein 9 homolog

Protein Summary
Description
Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. This gene encodes a protein thought to be a component of the radial spoke head in motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia 12. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372163
  • ENSP00000361236
  • ENSG00000172426
  • ENST00000372165
  • ENSP00000361238

Symbol
  • C6orf206
  • MRPS18AL1
  • CILD12
  • C6orf206
  • MRPS18AL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.59
tissue sample
0.56
cell line
0.52
transcription factor perturbation
0.47
virus perturbation
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
ZC3H4
Tbio
Novelty:  0.14897433
p_int:  0.999975826
p_ni:  0.000018754
p_wrong:  0.00000542
Score:  0.527
Data Source:  BioPlex,STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
p_int:  0.999934988
p_ni:  0.000064421
p_wrong:  5.91e-7
Score:  0.21
Data Source:  BioPlex,STRINGDB
BCR
Tclin
Novelty:  0.00127709
p_int:  0.998266831
p_ni:  0.001732867
p_wrong:  3.02e-7
Score:  0.167
Data Source:  BioPlex,STRINGDB
PPP1R10
Tbio
Family:  Enzyme
Novelty:  0.01119155
p_int:  0.996463022
p_ni:  0.003535104
p_wrong:  0.000001874
Score:  0.2
Data Source:  BioPlex,STRINGDB
EIF3H
Tbio
Novelty:  0.02564681
p_int:  0.995725305
p_ni:  0.004274695
Score:  0.812
Data Source:  BioPlex,STRINGDB
EIF3A
Tbio
Novelty:  0.00434615
p_int:  0.983007521
p_ni:  0.016992479
Score:  0.722
Data Source:  BioPlex,STRINGDB
MOCS3
Tbio
Family:  Enzyme
Novelty:  0.039209
p_int:  0.976816471
p_ni:  0.023183529
Score:  0.187
Data Source:  BioPlex,STRINGDB
EIF3C
Tbio
Novelty:  0.02844331
p_int:  0.842545323
p_ni:  0.157454677
Score:  0.722
Data Source:  BioPlex,STRINGDB
EIF3B
Tbio
Novelty:  0.00889042
p_int:  0.770790161
p_ni:  0.229209839
Score:  0.812
Data Source:  BioPlex,STRINGDB
EIF3E
Tbio
Novelty:  0.02154456
p_int:  0.761313261
p_ni:  0.238686739
Score:  0.809
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
3
3
92.9
hemoglobin measurement
3
3
4
89.8
platelet crit
1
2
2
53.2
body mass index
2
1
2
52
platelet count
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
92.9
hemoglobin measurement
4
89.8
platelet crit
2
53.2
body mass index
2
52
platelet count
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
radial spoke head 9 homolog
701263
Mouse
MGI:1922814
75564
Rat
RGD:1310693
316238
Dog
radial spoke head 9 homolog
609573
Cow
radial spoke head 9 homolog
VGNC:34187
523327
Species
Name
OMA
EggNOG
Inparanoid
Macaque
radial spoke head 9 homolog
Mouse
Rat
Dog
radial spoke head 9 homolog
Cow
radial spoke head 9 homolog
Publication Statistics
PubMed Score 14.20
PubMed score by year
PubTator Score 5.54
PubTator score by year
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Related Publications
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PMID
Year
Title