You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
RSPH6A
Radial spoke head protein 6 homolog A

Protein Summary
Description
The protein encoded by this gene is similar to a sea urchin radial spoke head protein. Radial spoke protein complexes form part of the axoneme of eukaryotic flagella and are located between the axoneme's outer ring of doublet microtubules and central pair of microtubules. In Chlamydomonas, radial spoke proteins are thought to regulate the activity of dynein and the symmetry of flagellar bending patterns. This gene maps to a region of chromosome 19 that is linked to primary ciliary dyskinesia-2 (CILD2). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221538
  • ENSP00000221538
  • ENSG00000104941

Symbol
  • RSHL1
  • RSP4
  • RSP6
  • RSHL1
  • RSPH4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
cell line
0.6
cell type or tissue
0.6
transcription factor binding site profile
0.45
tissue
0.38


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.05   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.05   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
MYH1
Tbio
Novelty:  0.00472973
p_int:  0.999999999
p_ni:  1e-9
Data Source:  BioPlex
MYH13
Tbio
Novelty:  0.01077846
p_int:  0.999999999
Data Source:  BioPlex
MYH2
Tbio
Novelty:  0.00365878
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  1e-9
Data Source:  BioPlex
MYLPF
Tbio
Novelty:  0.00960325
p_int:  0.999999997
p_ni:  3e-9
Data Source:  BioPlex
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.999999988
p_ni:  1.2e-8
Data Source:  BioPlex
ACTN3
Tbio
Novelty:  0.00375035
p_int:  0.99999998
p_ni:  1.9e-8
p_wrong:  1e-9
Data Source:  BioPlex
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.999999977
p_ni:  2.3e-8
Data Source:  BioPlex
TNNT3
Tbio
Novelty:  0.0212335
p_int:  0.999999955
p_ni:  2e-8
p_wrong:  2.4e-8
Data Source:  BioPlex
MYH8
Tbio
Novelty:  0.01020559
p_int:  0.999999953
p_ni:  4.7e-8
Data Source:  BioPlex
CKM
Tbio
Family:  Kinase
Novelty:  0.00239628
p_int:  0.999999918
p_ni:  3.7e-8
p_wrong:  4.5e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
4
5
97.1
total cholesterol measurement
1
3
3
94.5
apolipoprotein B measurement
2
2
3
94.1
eosinophil count
2
4
4
91.7
testosterone measurement
4
4
4
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
97.1
total cholesterol measurement
3
94.5
apolipoprotein B measurement
3
94.1
eosinophil count
4
91.7
testosterone measurement
4
90.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
radial spoke head 6 homolog A
VGNC:10162
468923
Mouse
MGI:1927643
83434
Rat
RGD:1306786
292684
Dog
radial spoke head 6 homolog A
VGNC:45781
476432
Cow
radial spoke head 6 homolog A
VGNC:34186
505298
Species
Name
OMA
EggNOG
Inparanoid
Chimp
radial spoke head 6 homolog A
Mouse
Rat
Dog
radial spoke head 6 homolog A
Cow
radial spoke head 6 homolog A
Publication Statistics
PubMed Score 28.05
PubMed score by year
PubTator Score 5.87
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title