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Tbio
RSPH4A
Radial spoke head protein 4 homolog A

Protein Summary
Description
Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. This gene encodes a protein that appears to be a component the radial spoke head, as determined by homology to similar proteins in the biflagellate alga Chlamydomonas reinhardtii and other ciliates. Radial spokes, which are regularly spaced along cilia, sperm, and flagella axonemes, consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of microtubules and dynein. Mutations in this gene cause primary ciliary dyskinesia 1, a disease arising from dysmotility of motile cilia and sperm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229554
  • ENSP00000229554
  • ENSG00000111834
  • ENST00000368580
  • ENSP00000357569
  • ENST00000368581
  • ENSP00000357570

Symbol
  • RSHL3
  • RSHL3
  • CILD11
  • RSPH6B
  • dJ412I7.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
cell type or tissue
0.74
cellular component
0.72
gene perturbation
0.65
tissue sample
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.88   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.88   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
NFYC
Tbio
Family:  TF
Novelty:  0.00626931
p_int:  0.916364387
p_ni:  0.005055949
p_wrong:  0.078579664
Data Source:  BioPlex
RSPH9
Tbio
Novelty:  0.08651313
Score:  0.972
Data Source:  STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
Score:  0.855
Data Source:  STRINGDB
DNAH5
Tbio
Novelty:  0.01579144
Score:  0.852
Data Source:  STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
Score:  0.85
Data Source:  STRINGDB
DNAI2
Tbio
Novelty:  0.02801096
Score:  0.843
Data Source:  STRINGDB
CCDC39
Tbio
Novelty:  0.0150835
Score:  0.835
Data Source:  STRINGDB
RSPH1
Tbio
Novelty:  0.02982525
Score:  0.799
Data Source:  STRINGDB
CCDC114
Tbio
Novelty:  0.12534741
Score:  0.798
Data Source:  STRINGDB
DNAH11
Tbio
Novelty:  0.02448234
Score:  0.797
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SYSCILIA_CCNET
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred by Curator (IC)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
radial spoke head 4 homolog A
VGNC:9650
743158
Macaque
radial spoke head 4 homolog A
715669
Mouse
MGI:3027894
212892
Rat
RGD:1307229
309767
Dog
radial spoke head 4 homolog A
VGNC:45780
484093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
radial spoke head 4 homolog A
Macaque
radial spoke head 4 homolog A
Mouse
Rat
Dog
radial spoke head 4 homolog A
Publication Statistics
PubMed Score 16.88
PubMed score by year
PubTator Score 4.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title