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Tbio
RSL1D1
Ribosomal L1 domain-containing protein 1

Protein Summary
Description
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000571133
  • ENSP00000460871
  • ENSG00000171490

Symbol
  • CATX11
  • CSIG
  • PBK1
  • L12
  • CSIG
  • PBK1
  • UTP30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
drug perturbation
0.96
disease perturbation
0.95
virus perturbation
0.95
histone modification site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.72   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.72   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (323)
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.83078596
p_ni:  0.16921404
Data Source:  BioPlex
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.798477689
p_ni:  0.201522311
Score:  0.526
Data Source:  BioPlex,STRINGDB
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.765719789
p_ni:  0.234280211
Score:  0.958
Data Source:  BioPlex,STRINGDB
NOP56
Tbio
Novelty:  0.01256937
Score:  0.997
Data Source:  STRINGDB
NOP58
Tbio
Novelty:  0.02148045
Score:  0.996
Data Source:  STRINGDB
BMS1
Tbio
Novelty:  0.0349992
Score:  0.995
Data Source:  STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
Score:  0.994
Data Source:  STRINGDB
RRS1
Tbio
Novelty:  0.01643671
Score:  0.994
Data Source:  STRINGDB
NOP2
Tbio
Family:  Enzyme
Novelty:  0.01664777
Score:  0.993
Data Source:  STRINGDB
WDR3
Tbio
Novelty:  0.15410886
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Senescence and Autophagy in Cancer
WikiPathways
Senescence and Autophagy in Cancer
WikiPathways
Senescence and Autophagy in Cancer
WikiPathways
Senescence and Autophagy in Cancer
WikiPathways
Glucose Homeostasis
Name
Explore in Pharos
Explore in Source
Senescence and Autophagy in Cancer
Senescence and Autophagy in Cancer
Senescence and Autophagy in Cancer
Senescence and Autophagy in Cancer
Glucose Homeostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
81.4
reticulocyte measurement
3
2
4
80
reticulocyte count
1
1
1
61.4
testosterone measurement
2
2
2
60.8
red blood cell density measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
81.4
reticulocyte measurement
4
80
reticulocyte count
1
61.4
testosterone measurement
2
60.8
red blood cell density measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal L1 domain containing 1
VGNC:13763
453927
Macaque
ribosomal L1 domain containing 1
712064
Mouse
MGI:1913659
66409
Dog
ribosomal L1 domain containing 1
VGNC:45775
479847
Horse
ribosomal L1 domain containing 1
VGNC:51229
100056041
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal L1 domain containing 1
Macaque
ribosomal L1 domain containing 1
Mouse
Dog
ribosomal L1 domain containing 1
Horse
ribosomal L1 domain containing 1
Publication Statistics
PubMed Score 22.72
PubMed score by year
PubTator Score 14.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title