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Tbio
RSF1
Remodeling and spacing factor 1

Protein Summary
Description
Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308488
  • ENSP00000311513
  • ENSG00000048649
  • ENST00000480887
  • ENSP00000434509

Symbol
  • HBXAP
  • XAP8
  • XAP8
  • p325
  • HBXAP
  • RSF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.84
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.81
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.14   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.14   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
HMGN1
Tbio
Novelty:  0.00492501
p_int:  0.995324742
p_ni:  0.000002749
p_wrong:  0.004672509
Data Source:  BioPlex
SMARCA5
Tbio
Novelty:  0.00518484
Score:  0.989
Data Source:  Reactome,STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
Score:  0.967
Data Source:  STRINGDB
CENPA
Tbio
Novelty:  0.00154245
Score:  0.957
Data Source:  Reactome,STRINGDB
CENPX
Tbio
Novelty:  0.08344454
Score:  0.947
Data Source:  STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.944
Data Source:  STRINGDB
HJURP
Tbio
Novelty:  0.02317704
Score:  0.938
Data Source:  STRINGDB
MIS18BP1
Tbio
Novelty:  0.05688807
Score:  0.929
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.928
Data Source:  STRINGDB
CENPC
Tbio
Novelty:  0.00638662
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
Deposition of new CENPA-containing nucleosomes at the centromere
Reactome
Nucleosome assembly
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromosome Maintenance
Deposition of new CENPA-containing nucleosomes at the centromere
Nucleosome assembly
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
74
diastolic blood pressure
2
3
3
73.8
platelet count
2
2
2
66.8
sex hormone-binding globulin measurement
2
1
2
30.9
mean reticulocyte volume
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
74
diastolic blood pressure
3
73.8
platelet count
2
66.8
sex hormone-binding globulin measurement
2
30.9
mean reticulocyte volume
1
22.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
remodeling and spacing factor 1
VGNC:11664
451441
Macaque
remodeling and spacing factor 1
699078
Mouse
MGI:2682305
233532
Rat
RGD:1311245
308839
Dog
remodeling and spacing factor 1
VGNC:45773
476797
Species
Name
OMA
EggNOG
Inparanoid
Chimp
remodeling and spacing factor 1
Macaque
remodeling and spacing factor 1
Mouse
Rat
Dog
remodeling and spacing factor 1
Publication Statistics
PubMed Score 93.14
PubMed score by year
PubTator Score 44.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title