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Tbio
RSBN1
Lysine-specific demethylase 9

Protein Summary
Description
Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261441
  • ENSP00000261441
  • ENSG00000081019
  • ENST00000612242
  • ENSP00000479490

Symbol
  • KDM9
  • ROSBIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
kinase perturbation
0.91
transcription factor perturbation
0.68
microRNA
0.64
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.92   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.92   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
RSBN1L
Tdark
Novelty:  5.23364486
p_int:  0.999944715
p_ni:  0.000055284
Score:  0.622
Data Source:  BioPlex,STRINGDB
SPTBN4
Tbio
Novelty:  0.02182293
p_int:  0.9988364
p_ni:  0.000002402
p_wrong:  0.001161197
Score:  0.165
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.995883444
p_ni:  0.004116556
Data Source:  BioPlex
ZNF317
Tdark
Family:  TF
Novelty:  1.58030176
p_int:  0.990477753
p_ni:  0.009447349
p_wrong:  0.000074898
Score:  0.489
Data Source:  BioPlex,STRINGDB
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
p_int:  0.987699496
p_ni:  0.012300504
Score:  0.186
Data Source:  BioPlex,STRINGDB
CDK11B
Tchem
Family:  Kinase
Novelty:  0.02711308
p_int:  0.987640213
p_ni:  0.012359787
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.987130044
p_ni:  0.012867871
p_wrong:  0.000002086
Data Source:  BioPlex
ZRANB2
Tbio
Novelty:  0.06105086
p_int:  0.981006918
p_ni:  0.018993082
Score:  0.216
Data Source:  BioPlex,STRINGDB
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
p_int:  0.973366188
p_ni:  0.026633812
Score:  0.197
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.969400264
p_ni:  0.030599736
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
4
3
1.7
98.3
5
3
0
1.9
96.5
autoimmune thyroid disease
3
2
0
1.7
95.6
2
2
0
1.5
94.8
8
3
0
1.4
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.7
98.3
0
1.9
96.5
autoimmune thyroid disease
0
1.7
95.6
0
1.5
94.8
0
1.4
92.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
round spermatid basic protein 1
VGNC:1505
457135
Macaque
round spermatid basic protein 1
707312
Mouse
MGI:2444993
229675
Rat
RGD:1307231
310749
Dog
round spermatid basic protein 1
VGNC:45771
475802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
round spermatid basic protein 1
Macaque
round spermatid basic protein 1
Mouse
Rat
Dog
round spermatid basic protein 1
Publication Statistics
PubMed Score 6.92
PubMed score by year
PubTator Score 2.78
PubTator score by year
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Related Publications
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PMID
Year
Title