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Tdark
RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

Protein Summary
Description
May be involved in porphyrin cofactor biosynthesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258955
  • ENSP00000258955
  • ENSG00000136444
  • ENST00000515221
  • ENSP00000424558

Symbol
  • HemW
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
protein domain
0.73
histone modification site profile
0.69
transcription factor perturbation
0.68
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.88   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.88   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
WDR53
Tdark
Novelty:  0.9750546
p_int:  0.994794609
p_ni:  0.005205391
Score:  0.534
Data Source:  BioPlex,STRINGDB
FBLN2
Tbio
Novelty:  0.01340024
p_int:  0.993477177
p_ni:  0.006522823
Data Source:  BioPlex
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
p_int:  0.991438989
p_ni:  0.008561011
Score:  0.194
Data Source:  BioPlex,STRINGDB
RTCA
Tbio
Family:  Enzyme
Novelty:  0.03086235
p_int:  0.958410319
p_ni:  0.041589681
Data Source:  BioPlex
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.950229978
p_ni:  0.049770022
Data Source:  BioPlex
LIG3
Tbio
Family:  Enzyme
Novelty:  0.00809038
p_int:  0.911316096
p_ni:  0.088683904
Score:  0.211
Data Source:  BioPlex,STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.877791561
p_ni:  0.122208439
Data Source:  BioPlex
PNLIP
Tclin
Family:  Enzyme
Novelty:  0.00043254
p_int:  0.870073608
p_ni:  0.129926392
Score:  0.23
Data Source:  BioPlex,STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
p_int:  0.845125972
p_ni:  0.154874028
Score:  0.176
Data Source:  BioPlex,STRINGDB
RRNAD1
Tdark
Novelty:  0.05443336
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
77.1
risk-taking behaviour
1
2
2
54.2
reticulocyte count
2
2
2
52.3
hip circumference
1
2
2
47.5
sex hormone-binding globulin measurement
2
1
2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
77.1
risk-taking behaviour
2
54.2
reticulocyte count
2
52.3
hip circumference
2
47.5
sex hormone-binding globulin measurement
2
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
radical S-adenosyl methionine domain containing 1
VGNC:9580
455175
Macaque
radical S-adenosyl methionine domain containing 1
705626
Mouse
MGI:3039628
237926
Horse
radical S-adenosyl methionine domain containing 1
VGNC:22594
100069955
Cow
radical S-adenosyl methionine domain containing 1
VGNC:34175
615755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
radical S-adenosyl methionine domain containing 1
Macaque
radical S-adenosyl methionine domain containing 1
Mouse
Horse
radical S-adenosyl methionine domain containing 1
Cow
radical S-adenosyl methionine domain containing 1
Publication Statistics
PubMed Score 1.88
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
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PMID
Year
Title