You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RS1
Retinoschisin

Protein Summary
Description
Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009). This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379984
  • ENSP00000369320
  • ENSG00000102104

Symbol
  • XLRS1
  • RS
  • XLRS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
molecular function
0.67
biological term
0.63
microRNA
0.62
gene perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.96   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.96   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
SARM1
Tchem
Novelty:  0.00510488
Score:  0.928
Data Source:  STRINGDB
ATP1A3
Tclin
Family:  Transporter
Novelty:  0.00485594
Score:  0.924
Data Source:  STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.913
Data Source:  STRINGDB
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
Score:  0.781
Data Source:  STRINGDB
ATP1A1
Tclin
Family:  Transporter
Novelty:  0.01078788
Score:  0.76
Data Source:  STRINGDB
PLIN2
Tbio
Novelty:  0.0020792
Score:  0.621
Data Source:  STRINGDB
AIPL1
Tbio
Novelty:  0.01436649
Score:  0.609
Data Source:  STRINGDB
NR2E3
Tchem
Family:  NR
Novelty:  0.00643343
Score:  0.599
Data Source:  STRINGDB
CDKL5
Tchem
Family:  Kinase
Novelty:  0.00444062
Score:  0.596
Data Source:  STRINGDB
ABCA4
Tbio
Family:  Transporter
Novelty:  0.00162903
Score:  0.589
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
55.8
glomerular filtration rate
1
1
0
6.1
25.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
55.8
glomerular filtration rate
0
6.1
25.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinoschisin 1 [Source:HGNC Symbol;Acc:HGNC:10457]
Macaque
retinoschisin 1
100423325
Mouse
MGI:1336189
20147
Rat
RGD:1642515
100125595
Dog
retinoschisin 1
VGNC:45769
491762
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinoschisin 1 [Source:HGNC Symbol;Acc:HGNC:10457]
Macaque
retinoschisin 1
Mouse
Rat
Dog
retinoschisin 1
Publication Statistics
PubMed Score 210.96
PubMed score by year
PubTator Score 429.37
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title