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Tbio
RRS1
Ribosome biogenesis regulatory protein homolog

Protein Summary
Description
Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320270
  • ENSP00000322396
  • ENSG00000179041

Symbol
  • KIAA0112
  • RRR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
small molecule perturbation
0.92
interacting protein
0.83
virus perturbation
0.83
PubMedID
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.03   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.03   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (434)
HIST2H2AC
Tbio
Novelty:  0.00065524
p_int:  0.999998913
p_ni:  2.1e-8
p_wrong:  0.000001066
Score:  0.152
Data Source:  BioPlex,STRINGDB
RPS3
Tbio
Novelty:  0.003106
p_int:  0.998798099
p_ni:  0.001201901
Score:  0.248
Data Source:  BioPlex,STRINGDB
APOBEC3C
Tbio
Novelty:  0.00882074
p_int:  0.998026323
p_ni:  0.001156628
p_wrong:  0.000817049
Data Source:  BioPlex
PURB
Tbio
Novelty:  0.02303518
p_int:  0.997801757
p_ni:  0.002198223
p_wrong:  2e-8
Score:  0.542
Data Source:  BioPlex,STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
p_int:  0.997724474
p_ni:  0.002275526
Score:  0.335
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.996984645
p_ni:  0.003015355
Score:  0.441
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.994551463
p_ni:  0.005448537
Score:  0.836
Data Source:  BioPlex,STRINGDB
RPS18
Tbio
Novelty:  0.00688684
p_int:  0.993863998
p_ni:  0.006136002
Score:  0.243
Data Source:  BioPlex,STRINGDB
YBX1
Tbio
Family:  TF
Novelty:  0.00132108
p_int:  0.99310624
p_ni:  0.00689376
Score:  0.286
Data Source:  BioPlex,STRINGDB
TRIM71
Tbio
Family:  Enzyme
Novelty:  0.01164618
p_int:  0.991673227
p_ni:  0.008326773
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
2
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosome biogenesis regulator homolog
VGNC:14580
747772
Macaque
ribosome biogenesis regulator homolog
711788
Mouse
MGI:1929721
59014
Rat
RGD:1311403
297784
Dog
ribosome biogenesis regulator homolog
VGNC:45768
486978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosome biogenesis regulator homolog
Macaque
ribosome biogenesis regulator homolog
Mouse
Rat
Dog
ribosome biogenesis regulator homolog
Publication Statistics
PubMed Score 69.03
PubMed score by year
PubTator Score 29.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title