You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RRP9
U3 small nucleolar RNA-interacting protein 2

Protein Summary
Description
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA. This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232888
  • ENSP00000232888
  • ENSG00000114767

Symbol
  • RNU3IP2
  • U355K
  • U3-55K
  • RNU3IP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
disease perturbation
0.79
gene perturbation
0.77
transcription factor binding site profile
0.75
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (397)
DOCK6
Tbio
Novelty:  0.01111596
p_int:  0.999996815
p_ni:  0.000003185
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999765853
p_ni:  0.000232494
p_wrong:  0.000001653
Data Source:  BioPlex
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.998345128
p_ni:  0.001654872
Score:  0.999
Data Source:  BioPlex,STRINGDB
NUDC
Tbio
Novelty:  0.01706012
p_int:  0.997992571
p_ni:  0.002007429
Score:  0.226
Data Source:  BioPlex,STRINGDB
TGS1
Tbio
Family:  Enzyme
Novelty:  0.03390504
p_int:  0.996401206
p_ni:  0.003593167
p_wrong:  0.000005627
Score:  0.173
Data Source:  BioPlex,STRINGDB
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.989984684
p_ni:  0.010015316
Score:  0.28
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.961911506
p_ni:  0.038088494
Score:  0.213
Data Source:  BioPlex,STRINGDB
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.881200191
p_ni:  0.118799809
Score:  0.846
Data Source:  BioPlex,STRINGDB
IL17B
Tbio
Novelty:  0.02825795
p_int:  0.864603656
p_ni:  0.135396344
Data Source:  BioPlex
SNU13
Tbio
Novelty:  0.01613497
p_int:  0.84855472
p_ni:  0.15144528
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
69.4
macrophage inflammatory protein 1b measurement
1
1
1
33.1
urate measurement
1
1
1
12.2
high density lipoprotein cholesterol measurement
1
1
1
10.6
apolipoprotein A 1 measurement
1
1
1
8.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
69.4
macrophage inflammatory protein 1b measurement
1
33.1
urate measurement
1
12.2
high density lipoprotein cholesterol measurement
1
10.6
apolipoprotein A 1 measurement
1
8.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
VGNC:48876
460407
Macaque
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
699421
Mouse
MGI:2384313
27966
Rat
RGD:1307881
363134
Dog
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
VGNC:45767
100688117
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
Macaque
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
Mouse
Rat
Dog
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
Publication Statistics
PubMed Score 14.19
PubMed score by year
PubTator Score 4.44
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title