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Tbio
RRP1
Ribosomal RNA processing protein 1 homolog A

Protein Summary
Description
Plays a critical role in the generation of 28S rRNA. The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000497547
  • ENSP00000417464
  • ENSG00000160214

Symbol
  • D21S2056E
  • NNP1
  • NOP52
  • RRP1A
  • NNP-1
  • NOP52
  • RRP1A
  • D21S2056E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.89
transcription factor
0.79
transcription factor binding site profile
0.75
histone modification site profile
0.73
cell type or tissue
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.58   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.58   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (270)
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.999986779
p_ni:  0.000013221
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.999971217
p_ni:  0.000028783
Data Source:  BioPlex
MOGS
Tbio
Family:  Enzyme
Novelty:  0.00527993
p_int:  0.999967543
p_ni:  0.000032457
Data Source:  BioPlex
MAK16
Tdark
Novelty:  0.07717917
p_int:  0.999946515
p_ni:  0.000053485
Score:  0.978
Data Source:  BioPlex,STRINGDB
TNFRSF13B
Tbio
Novelty:  0.00338954
p_int:  0.9997464
p_ni:  0.0002536
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.99952585
p_ni:  0.000474147
p_wrong:  3e-9
Data Source:  BioPlex
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.998774958
p_ni:  0.001225042
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.996651585
p_ni:  0.003348414
Data Source:  BioPlex
CHST8
Tbio
Family:  Enzyme
Novelty:  0.03489772
p_int:  0.992333342
p_ni:  0.007666657
Data Source:  BioPlex
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.991170431
p_ni:  0.008829565
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cystatin B measurement
1
2
2
91.4
blood protein measurement
1
1
1
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cystatin B measurement
2
91.4
blood protein measurement
1
47.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal RNA processing 1
VGNC:1128
474032
Macaque
ribosomal RNA processing 1
713435
Mouse
MGI:1203500
18114
Rat
RGD:1307286
309674
Dog
ribosomal RNA processing 1
VGNC:45763
478425
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal RNA processing 1
Macaque
ribosomal RNA processing 1
Mouse
Rat
Dog
ribosomal RNA processing 1
Publication Statistics
PubMed Score 8.58
PubMed score by year
PubTator Score 15.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title