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Tbio
RRAS2
Ras-related protein R-Ras2

Protein Summary
Description
It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256196
  • ENSP00000256196
  • ENSG00000133818
  • ENST00000414023
  • ENSP00000403282
  • ENST00000526063
  • ENSP00000434104
  • ENST00000529237
  • ENSP00000433230
  • ENST00000532814
  • ENSP00000431954
  • ENST00000534746
  • ENSP00000437083
  • ENST00000537760
  • ENSP00000437547

Symbol
  • TC21
  • TC21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.94
molecular function
0.91
interacting protein
0.9
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.81   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.81   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (158)
RIN1
Tbio
Novelty:  0.02401084
p_int:  0.97122315
p_ni:  0.02877685
Score:  0.91
Data Source:  BioPlex,STRINGDB
RGL1
Tbio
Novelty:  0.0095933
p_int:  0.960530839
p_ni:  0.039469161
Score:  0.895
Data Source:  BioPlex,STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.965
Data Source:  STRINGDB
AFDN
Tbio
Novelty:  0.00372947
Score:  0.951
Data Source:  STRINGDB
ARAF
Tchem
Family:  Kinase
Novelty:  0.00432488
Score:  0.948
Data Source:  STRINGDB
RALGDS
Tbio
Novelty:  0.00362484
Score:  0.944
Data Source:  STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.943
Data Source:  STRINGDB
PIK3CD
Tclin
Family:  Kinase
Novelty:  0.00572779
Score:  0.937
Data Source:  STRINGDB
SOS1
Tchem
Novelty:  0.00285343
Score:  0.933
Data Source:  STRINGDB
NF1
Tbio
Novelty:  0.00019092
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (63)
Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Autophagy - animal
KEGG
Regulation of actin cytoskeleton
KEGG
Mitophagy - animal
KEGG
C-type lectin receptor signaling pathway
KEGG
cAMP signaling pathway
Name
Explore in Pharos
Explore in Source
Autophagy - animal
Regulation of actin cytoskeleton
Mitophagy - animal
C-type lectin receptor signaling pathway
cAMP signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
7
16
20
10.8
99.9
BMI-adjusted hip circumference
2
10
10
94.6
body height
2
2
2
92.7
hip circumference
1
5
5
84.9
BMI-adjusted waist-hip ratio
1
9
9
76.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
20
10.8
99.9
BMI-adjusted hip circumference
10
94.6
body height
2
92.7
hip circumference
5
84.9
BMI-adjusted waist-hip ratio
9
76.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS related 2
VGNC:48881
451038
Macaque
RAS related 2
699700
Mouse
MGI:1914172
66922
Rat
RGD:1310793
365355
Dog
RAS related 2
VGNC:49613
476865
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS related 2
Macaque
RAS related 2
Mouse
Rat
Dog
RAS related 2
Publication Statistics
PubMed Score 65.81
PubMed score by year
PubTator Score 32.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title