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Tbio
RRAGD
Ras-related GTP-binding protein D

Protein Summary
Description
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359203
  • ENSP00000352131
  • ENSG00000025039
  • ENST00000369415
  • ENSP00000358423

Symbol
  • RAGD
  • bA11D8.2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.99
kinase perturbation
0.97
gene perturbation
0.96
molecular function
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
RRAGA
Tbio
Novelty:  0.02022668
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999999936
p_ni:  6.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR1
Tbio
Novelty:  0.04952213
p_int:  0.99999989
p_ni:  1.1e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR3
Tbio
Novelty:  0.050644
p_int:  0.999999863
p_ni:  1.35e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR4
Tdark
Novelty:  0.24218646
p_int:  0.999999738
p_ni:  2.62e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.965647788
p_ni:  0.002557633
p_wrong:  0.031794579
Data Source:  BioPlex
SLC38A9
Tbio
Family:  Transporter
Novelty:  0.0879703
Score:  0.999
Data Source:  Reactome,STRINGDB
LAMTOR2
Tbio
Novelty:  0.05210182
Score:  0.998
Data Source:  STRINGDB
RRAGB
Tbio
Novelty:  0.02279777
Score:  0.998
Data Source:  Reactome,STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
Score:  0.998
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
68.1
urate measurement
2
2
2
49.2
creatinine measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
68.1
urate measurement
2
49.2
creatinine measurement
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras related GTP binding D
VGNC:11219
462884
Macaque
Ras related GTP binding D
702798
Mouse
MGI:1098604
52187
Rat
RGD:1310007
297960
Dog
Ras related GTP binding D
VGNC:49747
474994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras related GTP binding D
Macaque
Ras related GTP binding D
Mouse
Rat
Dog
Ras related GTP binding D
Publication Statistics
PubMed Score 20.03
PubMed score by year
PubTator Score 1.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title