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Tbio
RRAGC
Ras-related GTP-binding protein C

Protein Summary
Description
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373001
  • ENSP00000362092
  • ENSG00000116954

Symbol
  • GTR2
  • RAGC
  • TIB929
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
molecular function
0.97
virus perturbation
0.92
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.84   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.84   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
RRAGA
Tbio
Novelty:  0.02022668
p_int:  0.999999995
p_ni:  1e-9
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LAMTOR3
Tbio
Novelty:  0.050644
p_int:  0.999996483
p_ni:  0.000003517
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999993852
p_ni:  0.000006148
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR1
Tbio
Novelty:  0.04952213
p_int:  0.999981584
p_ni:  0.000018411
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR4
Tdark
Novelty:  0.24218646
p_int:  0.999971883
p_ni:  0.000028117
Score:  0.999
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.998597143
p_ni:  0.001402383
p_wrong:  4.74e-7
Score:  0.515
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.998500343
p_ni:  0.001477602
p_wrong:  0.000022055
Score:  0.297
Data Source:  BioPlex,STRINGDB
LGALS9C
Tdark
Novelty:  0.29969898
p_int:  0.994556755
p_ni:  0.005443244
p_wrong:  1e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.967303114
p_ni:  0.032696868
p_wrong:  1.8e-8
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.924303984
p_ni:  0.07569562
p_wrong:  3.96e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
73.5
mathematical ability
3
2
3
51.7
myeloid white cell count
1
1
1
21.2
triglyceride measurement
1
1
1
17.8
leukocyte count
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
73.5
mathematical ability
3
51.7
myeloid white cell count
1
21.2
triglyceride measurement
1
17.8
leukocyte count
1
14
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras related GTP binding C
VGNC:8098
456772
Macaque
Ras related GTP binding C
715549
Mouse
MGI:1858751
54170
Rat
RGD:1311760
298514
Dog
Ras related GTP binding C
VGNC:45756
100685060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras related GTP binding C
Macaque
Ras related GTP binding C
Mouse
Rat
Dog
Ras related GTP binding C
Publication Statistics
PubMed Score 79.84
PubMed score by year
PubTator Score 12.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title