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Tbio
RRAGA
Ras-related GTP-binding protein A

Protein Summary
Description
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380527
  • ENSP00000369899
  • ENSG00000155876

Symbol
  • FIP1
  • RAGA
  • FIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
virus perturbation
0.96
transcription factor binding site profile
0.86
kinase perturbation
0.81
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.36   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.36   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
RRAGD
Tbio
Novelty:  0.04742375
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RRAGC
Tbio
Novelty:  0.01462756
p_int:  0.999999995
p_ni:  1e-9
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999999983
p_ni:  1e-9
p_wrong:  1.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
SLC38A9
Tbio
Family:  Transporter
Novelty:  0.0879703
p_int:  0.999994739
p_ni:  0.000005261
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PPP1R1A
Tbio
Family:  Enzyme
Novelty:  0.01565981
p_int:  0.999915857
p_ni:  0.000083758
p_wrong:  3.85e-7
Score:  0.247
Data Source:  BioPlex,STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
p_int:  0.995674172
p_ni:  0.004325828
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NPC2
Tbio
Novelty:  0.00342898
p_int:  0.977226785
p_ni:  0.022734452
p_wrong:  0.000038764
Score:  0.249
Data Source:  BioPlex,STRINGDB
DEPDC5
Tbio
Novelty:  0.0177511
Score:  0.999
Data Source:  STRINGDB
LAMTOR2
Tbio
Novelty:  0.05210182
Score:  0.999
Data Source:  STRINGDB
RRAGB
Tbio
Novelty:  0.02279777
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (96)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
E3 ubiquitin ligases ubiquitinate target proteins
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
SGD
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1
79.8
mean platelet volume
2
2
2
77.8
1
1
0
1.1
59.8
testosterone measurement
3
3
3
59
platelet count
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
79.8
mean platelet volume
2
77.8
0
1.1
59.8
testosterone measurement
3
59
platelet count
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras related GTP binding A
VGNC:13956
473118
Macaque
Ras related GTP binding A
100430225
Mouse
MGI:1915691
68441
Rat
RGD:619804
117044
Cow
Ras related GTP binding A
618207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras related GTP binding A
Macaque
Ras related GTP binding A
Mouse
Rat
Cow
Ras related GTP binding A
Publication Statistics
PubMed Score 53.36
PubMed score by year
PubTator Score 23.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title