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Tbio
RRAD
GTP-binding protein RAD

Protein Summary
Description
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299759
  • ENSP00000299759
  • ENSG00000166592
  • ENST00000420652
  • ENSP00000388744

Symbol
  • RAD
  • RAD
  • RAD1
  • REM3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
molecular function
0.93
PubMedID
0.87
protein domain
0.85
virus perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.98   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.98   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.721
Data Source:  STRINGDB
ERCC6
Tbio
Novelty:  0.00764502
Score:  0.659
Data Source:  STRINGDB
RAPGEFL1
Tdark
Novelty:  1.01382041
Score:  0.649
Data Source:  STRINGDB
NR4A3
Tbio
Family:  NR
Novelty:  0.00882077
Score:  0.589
Data Source:  STRINGDB
XPC
Tbio
Novelty:  0.00775175
Score:  0.588
Data Source:  STRINGDB
EHF
Tbio
Family:  TF
Novelty:  0.00990018
Score:  0.533
Data Source:  STRINGDB
KNDC1
Tdark
Novelty:  0.1459108
Score:  0.53
Data Source:  STRINGDB
GP5
Tbio
Novelty:  0.00095584
Score:  0.529
Data Source:  STRINGDB
TLR3
Tbio
Novelty:  0.00057048
Score:  0.524
Data Source:  STRINGDB
UQCRC1
Tbio
Family:  Enzyme
Novelty:  0.01746759
Score:  0.518
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
4
4
87.9
high density lipoprotein cholesterol measurement
2
3
4
83.3
heel bone mineral density
2
2
2
80.6
diastolic blood pressure
1
1
1
73.7
blood protein measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
4
87.9
high density lipoprotein cholesterol measurement
4
83.3
heel bone mineral density
2
80.6
diastolic blood pressure
1
73.7
blood protein measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
VGNC:10500
741038
Mouse
MGI:1930943
56437
Rat
RGD:69357
83521
Dog
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
VGNC:45755
611304
Horse
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
VGNC:22575
100065651
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Mouse
Rat
Dog
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Horse
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Publication Statistics
PubMed Score 367.98
PubMed score by year
PubTator Score 528.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title