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Tdark
RPUSD4
Mitochondrial RNA pseudouridine synthase RPUSD4

Protein Summary
Description
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298317
  • ENSP00000298317
  • ENSG00000165526
  • ENST00000533628
  • ENSP00000433065
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.89
disease perturbation
0.87
transcription factor binding site profile
0.76
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999999326
p_ni:  6.74e-7
Data Source:  BioPlex
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.99982073
p_ni:  0.00017927
Score:  0.176
Data Source:  BioPlex,STRINGDB
DDX28
Tbio
Family:  Enzyme
Novelty:  0.16760542
p_int:  0.999764421
p_ni:  0.000235571
p_wrong:  9e-9
Score:  0.924
Data Source:  BioPlex,STRINGDB
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.999210488
p_ni:  0.00078588
p_wrong:  0.000003632
Data Source:  BioPlex
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.998967325
p_ni:  0.001025938
p_wrong:  0.000006737
Data Source:  BioPlex
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.996273324
p_ni:  0.003726491
p_wrong:  1.86e-7
Score:  0.547
Data Source:  BioPlex,STRINGDB
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.994514224
p_ni:  0.005445838
p_wrong:  0.000039937
Data Source:  BioPlex
MRPL39
Tbio
Novelty:  0.14346457
p_int:  0.988939661
p_ni:  0.011045736
p_wrong:  0.000014603
Score:  0.397
Data Source:  BioPlex,STRINGDB
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.988005234
p_ni:  0.011871773
p_wrong:  0.000122992
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.912626397
p_ni:  0.087373601
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
5
5
90.8
low density lipoprotein cholesterol measurement
1
2
2
86.2
total cholesterol measurement
1
2
2
79.5
neutrophil percentage of granulocytes
1
1
1
53.7
eosinophil percentage of granulocytes
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
5
90.8
low density lipoprotein cholesterol measurement
2
86.2
total cholesterol measurement
2
79.5
neutrophil percentage of granulocytes
1
53.7
eosinophil percentage of granulocytes
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA pseudouridylate synthase domain containing 4
VGNC:11666
451652
Macaque
RNA pseudouridylate synthase domain containing 4
714162
Mouse
MGI:1919239
71989
Rat
RGD:1311268
315550
Dog
RNA pseudouridylate synthase domain containing 4
VGNC:45754
489295
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA pseudouridylate synthase domain containing 4
Macaque
RNA pseudouridylate synthase domain containing 4
Mouse
Rat
Dog
RNA pseudouridylate synthase domain containing 4
Publication Statistics
PubMed Score 2.39
PubMed score by year
PubTator Score 1.67
PubTator score by year
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Related Publications
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PMID
Year
Title