RPUSD4
Mitochondrial RNA pseudouridine synthase RPUSD4
Protein Summary
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).
- ENST00000298317
- ENSP00000298317
- ENSG00000165526
- ENST00000533628
- ENSP00000433065
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
histone modification site profile | 0.89 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.76 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.39 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 39 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.39 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 39 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (57)
MRPL12
Novelty: 0.10646542
p_int: 0.99982073
p_ni: 0.00017927
Score: 0.176
Data Source: BioPlex,STRINGDB
DDX28
Family: Enzyme
Novelty: 0.16760542
p_int: 0.999764421
p_ni: 0.000235571
p_wrong: 9e-9
Score: 0.924
Data Source: BioPlex,STRINGDB
MAP7
Novelty: 0.01976296
p_int: 0.999210488
p_ni: 0.00078588
p_wrong: 0.000003632
Data Source: BioPlex
TMED7
Novelty: 0.31193294
p_int: 0.998967325
p_ni: 0.001025938
p_wrong: 0.000006737
Data Source: BioPlex
MRPL4
Novelty: 0.27290276
p_int: 0.996273324
p_ni: 0.003726491
p_wrong: 1.86e-7
Score: 0.547
Data Source: BioPlex,STRINGDB
RNH1
Family: Enzyme
Novelty: 0.00307468
p_int: 0.994514224
p_ni: 0.005445838
p_wrong: 0.000039937
Data Source: BioPlex
MRPL39
Novelty: 0.14346457
p_int: 0.988939661
p_ni: 0.011045736
p_wrong: 0.000014603
Score: 0.397
Data Source: BioPlex,STRINGDB
RBM42
Novelty: 0.37655036
p_int: 0.988005234
p_ni: 0.011871773
p_wrong: 0.000122992
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (1)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein B measurement | 1 | 5 | 5 | 90.8 | |||||
low density lipoprotein cholesterol measurement | 1 | 2 | 2 | 86.2 | |||||
total cholesterol measurement | 1 | 2 | 2 | 79.5 | |||||
neutrophil percentage of granulocytes | 1 | 1 | 1 | 53.7 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein B measurement | 5 | 90.8 | |||||
low density lipoprotein cholesterol measurement | 2 | 86.2 | |||||
total cholesterol measurement | 2 | 79.5 | |||||
neutrophil percentage of granulocytes | 1 | 53.7 | |||||
eosinophil percentage of granulocytes | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | RNA pseudouridylate synthase domain containing 4 | VGNC:11666 | 451652 | |||||
Macaque | RNA pseudouridylate synthase domain containing 4 | 714162 | ||||||
Mouse | MGI:1919239 | 71989 | ||||||
Rat | RGD:1311268 | 315550 | ||||||
Dog | RNA pseudouridylate synthase domain containing 4 | VGNC:45754 | 489295 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | RNA pseudouridylate synthase domain containing 4 | |||||
Macaque | RNA pseudouridylate synthase domain containing 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | RNA pseudouridylate synthase domain containing 4 | |||||
Publication Statistics
PubMed Score 2.39
PubMed score by year
PubTator Score 1.67
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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