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Tdark
RPUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

Protein Summary
Description
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664). This gene encodes a protein that functions in the assembly of the mitochondrial ribosome by adding a pseudouridine group to 16S rRNA. Loss of this gene results in causes defects in mitochondrial protein production. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383820
  • ENSP00000373331
  • ENSG00000156990
  • ENST00000433535
  • ENSP00000398921
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
cellular component
0.75
tissue sample
0.62
interacting protein
0.6
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.94   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.94   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.998683007
p_ni:  0.001316993
Data Source:  BioPlex
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.997990955
p_ni:  0.002009045
Score:  0.168
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.977907135
p_ni:  0.022092863
p_wrong:  2e-9
Data Source:  BioPlex
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.967963095
p_ni:  0.032036905
Data Source:  BioPlex
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.961969211
p_ni:  0.038017299
p_wrong:  0.00001349
Data Source:  BioPlex
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
p_int:  0.943515948
p_ni:  0.056484052
Score:  0.686
Data Source:  BioPlex,STRINGDB
NIT1
Tbio
Family:  Enzyme
Novelty:  0.00498587
p_int:  0.909921637
p_ni:  0.090078362
Data Source:  BioPlex
MRPL4
Tbio
Novelty:  0.27290276
p_int:  0.906043423
p_ni:  0.093956577
Score:  0.28
Data Source:  BioPlex,STRINGDB
MINDY3
Tbio
Novelty:  0.02865765
p_int:  0.903306393
p_ni:  0.096693517
p_wrong:  9.1e-8
Data Source:  BioPlex
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.887579495
p_ni:  0.112420504
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
44.5
blood protein measurement
1
1
1
43.9
appendicular lean mass
1
1
1
37.7
educational attainment
1
1
1
9.7
body weight
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
44.5
blood protein measurement
1
43.9
appendicular lean mass
1
37.7
educational attainment
1
9.7
body weight
1
5.4
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RNA pseudouridylate synthase domain containing 3
700349
Mouse
MGI:2141440
101122
Rat
RGD:1307582
362416
Dog
RNA pseudouridylate synthase domain containing 3
VGNC:45753
484663
Horse
RNA pseudouridylate synthase domain containing 3
VGNC:22573
100058317
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RNA pseudouridylate synthase domain containing 3
Mouse
Rat
Dog
RNA pseudouridylate synthase domain containing 3
Horse
RNA pseudouridylate synthase domain containing 3
Publication Statistics
PubMed Score 0.94
PubMed score by year
PubTator Score 1.17
PubTator score by year
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Related Publications
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PMID
Year
Title