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Tbio
RPTOR
Regulatory-associated protein of mTOR

Protein Summary
Description
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylatin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306801
  • ENSP00000307272
  • ENSG00000141564
  • ENST00000544334
  • ENSP00000442479
  • ENST00000570891
  • ENSP00000460136

Symbol
  • KIAA1303
  • RAPTOR
  • KOG1
  • Mip1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.99
protein domain
0.97
drug perturbation
0.96
biological process
0.88
molecular function
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 775.93   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 554   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 775.93   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (315)
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.999507955
p_ni:  0.000492045
Score:  0.332
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999454998
p_ni:  0.000545002
Data Source:  BioPlex
LAMTOR3
Tbio
Novelty:  0.050644
p_int:  0.998995626
p_ni:  0.001004374
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.998544327
p_ni:  0.001455673
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRAGA
Tbio
Novelty:  0.02022668
p_int:  0.995674172
p_ni:  0.004325828
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
INTU
Tbio
Novelty:  0.02714388
p_int:  0.984333436
p_ni:  0.015666561
p_wrong:  3e-9
Data Source:  BioPlex
BAG3
Tbio
Novelty:  0.0042967
p_int:  0.978034201
p_ni:  0.021965799
Score:  0.309
Data Source:  BioPlex,STRINGDB
LAMTOR4
Tdark
Novelty:  0.24218646
p_int:  0.973268976
p_ni:  0.026731024
Score:  0.999
Data Source:  BioPlex,STRINGDB
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.971926306
p_ni:  0.02807369
p_wrong:  4e-9
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.962749565
p_ni:  0.037250435
Data Source:  BioPlex
Pathways (47)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Energy dependent regulation of mTOR by LKB1-AMPK
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
8
3
9
92.1
body height
1
1
1
73.2
comparative body size at age 10, self-reported
1
1
1
65.4
1
1
0
1.4
61.4
visceral adipose tissue measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
9
92.1
body height
1
73.2
comparative body size at age 10, self-reported
1
65.4
0
1.4
61.4
visceral adipose tissue measurement
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulatory associated protein of MTOR complex 1
VGNC:9579
454949
Mouse
MGI:1921620
74370
Rat
RGD:1311784
287871
Dog
regulatory associated protein of MTOR complex 1
VGNC:45750
608378
Horse
regulatory associated protein of MTOR complex 1
VGNC:22570
100056244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulatory associated protein of MTOR complex 1
Mouse
Rat
Dog
regulatory associated protein of MTOR complex 1
Horse
regulatory associated protein of MTOR complex 1
Publication Statistics
PubMed Score 775.93
PubMed score by year
PubTator Score 142.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title