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Tbio
RPTN
Repetin

Protein Summary
Description
Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316073
  • ENSP00000317895
  • ENSG00000215853
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.83
protein domain
0.73
gene perturbation
0.56
microRNA
0.53
cell type or tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
LOR
Tbio
Novelty:  0.0033781
Score:  0.967
Data Source:  STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.961
Data Source:  STRINGDB
SPRR2D
Tdark
Novelty:  0.28543054
Score:  0.959
Data Source:  STRINGDB
LCE1D
Tbio
Novelty:  0.52901166
Score:  0.949
Data Source:  STRINGDB
SPRR2G
Tdark
Novelty:  0.7198022
Score:  0.948
Data Source:  STRINGDB
SPRR2A
Tbio
Novelty:  0.07065019
Score:  0.948
Data Source:  STRINGDB
LCE5A
Tdark
Novelty:  0.94159494
Score:  0.946
Data Source:  STRINGDB
SPRR1B
Tbio
Novelty:  0.0320028
Score:  0.946
Data Source:  STRINGDB
CASP14
Tchem
Family:  Enzyme
Novelty:  0.01230567
Score:  0.945
Data Source:  STRINGDB
LCE3E
Tdark
Novelty:  0.72118892
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
6
7
98
hair shape measurement
1
2
2
98
asthma
6
3
1
1.2
94.2
hair morphology
1
1
0
6.1
92.9
vitamin D deficiency
1
1
1
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
7
98
hair shape measurement
2
98
asthma
1
1.2
94.2
hair morphology
0
6.1
92.9
vitamin D deficiency
1
91.7
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
repetin
VGNC:11013
100610036
Macaque
repetin
100425215
Mouse
MGI:1099055
20129
Rat
RGD:1311687
295190
Dog
repetin [Source:HGNC Symbol;Acc:HGNC:26809]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
repetin
Macaque
repetin
Mouse
Rat
Dog
repetin [Source:HGNC Symbol;Acc:HGNC:26809]
Publication Statistics
PubMed Score 11.43
PubMed score by year
PubTator Score 22.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title