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Tbio
RPS9
40S ribosomal protein S9

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302907
  • ENSP00000302896
  • ENSG00000170889
  • ENST00000391752
  • ENSP00000375632
  • ENST00000391753
  • ENSP00000375633
  • ENST00000610826
  • ENSP00000481764
  • ENSG00000278270
  • ENST00000611921
  • ENSP00000480662
  • ENSG00000274950
  • ENST00000614737
  • ENSP00000482338
  • ENST00000615346
  • ENSP00000481553
  • ENSG00000274646
  • ENST00000616082
  • ENSP00000482475
  • ENST00000616536
  • ENSP00000481822
  • ENST00000616877
  • ENSP00000481194
  • ENST00000619229
  • ENSP00000479917
  • ENST00000620940
  • ENSP00000483179

Symbol
  • S9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
hub protein
0.94
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.78   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.78   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (558)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.972876474
p_ni:  0.027123526
Score:  0.553
Data Source:  BioPlex,STRINGDB
RPL7L1
Tdark
Novelty:  0.78428937
p_int:  0.916099976
p_ni:  0.083900024
Score:  0.935
Data Source:  BioPlex,STRINGDB
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.847517257
p_ni:  0.152482743
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.80095347
p_ni:  0.19904653
Score:  0.213
Data Source:  BioPlex,STRINGDB
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.797027288
p_ni:  0.202972712
Data Source:  BioPlex
EBNA1BP2
Tbio
Novelty:  0.02083466
p_int:  0.773747416
p_ni:  0.226252584
Score:  0.776
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.771432877
p_ni:  0.228567123
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS4X
Tbio
Novelty:  0.01396038
Score:  0.999
Data Source:  STRINGDB
RPL14
Tbio
Novelty:  0.01600377
Score:  0.999
Data Source:  STRINGDB
RPL36
Tbio
Novelty:  0.02259932
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (336)
Items per page:
1 – 5 of 336
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
11
26
99.1
high density lipoprotein cholesterol measurement
13
11
26
99.1
high density lipoprotein cholesterol measurement
13
11
26
99.1
high density lipoprotein cholesterol measurement
13
11
26
99.1
alkaline phosphatase measurement
2
3
3
18.1
97.7
Items per page:
1 – 5 of 336
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
26
99.1
high density lipoprotein cholesterol measurement
26
99.1
high density lipoprotein cholesterol measurement
26
99.1
high density lipoprotein cholesterol measurement
26
99.1
alkaline phosphatase measurement
3
18.1
97.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S9
VGNC:12083
107966305
Macaque
ribosomal protein S9
694053
Mouse
MGI:1924096
76846
Rat
Dog
ribosomal protein S9
VGNC:45749
476387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S9
Macaque
ribosomal protein S9
Mouse
Rat
Dog
ribosomal protein S9
Publication Statistics
PubMed Score 68.78
PubMed score by year
PubTator Score 104.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title