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Tdark
RPS6KC1
Ribosomal protein S6 kinase delta-1

Protein Summary
Description
May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366959
  • ENSP00000355926
  • ENSG00000136643
  • ENST00000366960
  • ENSP00000355927

Symbol
  • RPK118
  • RSKL1
  • RPK118
  • S6PKh1
  • humS6PKh1
  • S6K-delta-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
chemical bioactivity profile
0.94
virus perturbation
0.94
kinase perturbation
0.84
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.34   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.34   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
VPS39
Tbio
Novelty:  0.02172601
p_int:  0.999999997
p_wrong:  3e-9
Score:  0.539
Data Source:  BioPlex,STRINGDB
DENND6A
Tbio
Novelty:  4.5572617
p_int:  0.999999997
p_ni:  2e-9
Score:  0.419
Data Source:  BioPlex,STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
Score:  0.677
Data Source:  STRINGDB
SPAG5
Tbio
Novelty:  0.02392116
Score:  0.676
Data Source:  STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
Score:  0.67
Data Source:  STRINGDB
PRDX3
Tbio
Family:  Enzyme
Novelty:  0.00340119
Score:  0.647
Data Source:  STRINGDB
NEK6
Tchem
Family:  Kinase
Novelty:  0.02394134
Score:  0.619
Data Source:  STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
Score:  0.562
Data Source:  STRINGDB
S100B
Tchem
Novelty:  0.00031007
Score:  0.553
Data Source:  STRINGDB
VDR
Tclin
Family:  NR
Novelty:  0.00058366
Score:  0.543
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
4
49.1
self reported educational attainment
1
2
2
38.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
49.1
self reported educational attainment
2
38.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase C1
VGNC:9455
457727
Macaque
ribosomal protein S6 kinase C1
709733
Mouse
MGI:2443419
320119
Rat
RGD:1306578
289342
Dog
ribosomal protein S6 kinase C1
VGNC:45746
490288
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase C1
Macaque
ribosomal protein S6 kinase C1
Mouse
Rat
Dog
ribosomal protein S6 kinase C1
Publication Statistics
PubMed Score 2.34
PubMed score by year
PubTator Score 2.98
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title