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Tchem
RPS6KB1
Ribosomal protein S6 kinase beta-1

Protein Summary
Description
Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225577
  • ENSP00000225577
  • ENSG00000108443
  • ENST00000393021
  • ENSP00000376744
  • ENST00000406116
  • ENSP00000384335
  • ENST00000443572
  • ENSP00000441993

Symbol
  • STK14A
  • S6K
  • PS6K
  • S6K1
  • STK14A
  • p70-S6K
  • p70 S6KA
  • p70-alpha
  • S6K-beta-1
  • p70(S6K)-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
hub protein
1
kinase
1
biological process
0.99
biological term
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2028.5   (req: < 5)
Gene RIFs: 237   (req: <= 3)
Antibodies: 2421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2028.5   (req: >= 5)
Gene RIFs: 237   (req: > 3)
Antibodies: 2421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 763
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (365)
UBL4A
Tbio
Novelty:  0.01278608
p_int:  0.999519845
p_ni:  0.000478804
p_wrong:  0.000001351
Score:  0.69
Data Source:  BioPlex,STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.999
Data Source:  Reactome,STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.999
Data Source:  Reactome,STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
Score:  0.998
Data Source:  STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.996
Data Source:  STRINGDB
PDPK1
Tchem
Family:  Kinase
Novelty:  0.00430458
Score:  0.995
Data Source:  STRINGDB
RHEB
Tbio
Family:  Enzyme
Novelty:  0.00313935
Score:  0.994
Data Source:  STRINGDB
EIF4B
Tbio
Novelty:  0.00665561
Score:  0.994
Data Source:  Reactome,STRINGDB
EIF4EBP1
Tbio
Novelty:  0.00098313
Score:  0.994
Data Source:  STRINGDB
POLDIP3
Tbio
Family:  Enzyme
Novelty:  0.03072373
Score:  0.993
Data Source:  STRINGDB
Pathways (112)
Signal Transduction (R-HSA-162582)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
mTOR signalling
Reactome
mTORC1-mediated signalling
Name
Explore in Pharos
Explore in Source
Signal Transduction
mTOR signalling
mTORC1-mediated signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (64)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
94.7
monocyte count
3
4
4
93.2
monocyte percentage of leukocytes
2
2
2
91.8
blood protein measurement
1
2
2
88.2
serum non-albumin protein measurement
1
2
2
86.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
94.7
monocyte count
4
93.2
monocyte percentage of leukocytes
2
91.8
blood protein measurement
2
88.2
serum non-albumin protein measurement
2
86.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase B1
VGNC:9577
468426
Macaque
ribosomal protein S6 kinase B1
711979
Mouse
MGI:1270849
72508
Rat
RGD:620683
83840
Dog
ribosomal protein S6 kinase B1
VGNC:45744
480580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase B1
Macaque
ribosomal protein S6 kinase B1
Mouse
Rat
Dog
ribosomal protein S6 kinase B1
Publication Statistics
PubMed Score 2028.50
PubMed score by year
PubTator Score 930.41
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title