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Tchem
RPS6KA5
Ribosomal protein S6 kinase alpha-5

Protein Summary
Description
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418736
  • ENSP00000402787
  • ENSG00000100784
  • ENST00000536315
  • ENSP00000442803
  • ENST00000614987
  • ENSP00000479667

Symbol
  • MSK1
  • MSK1
  • RLPK
  • MSPK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
co-expressed gene
0.97
molecular function
0.97
protein domain
0.97
interacting protein
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.01   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 854   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.01   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 854   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (87)
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999999996
p_ni:  4e-9
Data Source:  BioPlex
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.99999934
p_ni:  6.6e-7
Score:  0.963
Data Source:  BioPlex,Reactome,STRINGDB
HSP90AA4P
Tdark
p_int:  0.888006954
p_ni:  0.111992488
p_wrong:  5.58e-7
Data Source:  BioPlex
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.985
Data Source:  Reactome,STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.979
Data Source:  Reactome,STRINGDB
ATF1
Tchem
Family:  TF
Novelty:  0.01450941
Score:  0.976
Data Source:  Reactome,STRINGDB
EIF4EBP1
Tbio
Novelty:  0.00098313
Score:  0.972
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.964
Data Source:  Reactome,STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.963
Data Source:  Reactome,STRINGDB
HMGN1
Tbio
Novelty:  0.00492501
Score:  0.96
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (87)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
CREB phosphorylation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Axon guidance
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
CREB phosphorylation
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
6
7
95.7
waist-hip ratio
3
6
7
92.2
heel bone mineral density
2
2
3
91.3
bone density
1
3
3
77.8
waist circumference
1
4
4
76.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
7
95.7
waist-hip ratio
7
92.2
heel bone mineral density
3
91.3
bone density
3
77.8
waist circumference
4
76.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S6 kinase A5
699798
Mouse
MGI:1920336
73086
Dog
ribosomal protein S6 kinase A5
VGNC:45742
490831
Horse
ribosomal protein S6 kinase A5
VGNC:22561
100062953
Cow
ribosomal protein S6 kinase A5
VGNC:34144
504408
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S6 kinase A5
Mouse
Dog
ribosomal protein S6 kinase A5
Horse
ribosomal protein S6 kinase A5
Cow
ribosomal protein S6 kinase A5
Publication Statistics
PubMed Score 113.01
PubMed score by year
PubTator Score 90.06
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title