Tbio RPS6 40S ribosomal protein S6

Protein Summary

Description

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62753
• P08227
• P10660
• Q4VBY7
• Q8N6Z7

Gene Name

• RPS6

Ensembl ID

• ENST00000380394
• ENSP00000369757
• ENSG00000137154

Symbol

• S6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
drug perturbation	1
interacting protein	1
biological process	0.99
microRNA	0.95

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 40s Ribosomal Protein S6

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 40s Ribosomal Protein S6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 759.29   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 1161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 759.29   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 1161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0