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Tbio
RPS5
40S ribosomal protein S5

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000196551
  • ENSP00000196551
  • ENSG00000083845
  • ENST00000596046
  • ENSP00000472985
  • ENST00000601521
  • ENSP00000470114

Symbol
  • S5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.95
hub protein
0.94
transcription factor binding site profile
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.89   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.89   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (578)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.98166869
p_ni:  0.01833131
Score:  0.428
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.972703102
p_ni:  0.027296898
Score:  0.999
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.928669427
p_ni:  0.071330573
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.893445275
p_ni:  0.106554725
Score:  0.544
Data Source:  BioPlex,STRINGDB
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.885193089
p_ni:  0.114806911
Data Source:  BioPlex
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.829907597
p_ni:  0.170092403
Score:  0.999
Data Source:  BioPlex,STRINGDB
NOL12
Tbio
Novelty:  0.15925205
p_int:  0.810247357
p_ni:  0.189752643
Score:  0.589
Data Source:  BioPlex,STRINGDB
ZCRB1
Tdark
Novelty:  0.37592387
p_int:  0.79818559
p_ni:  0.201814409
p_wrong:  1e-9
Score:  0.746
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.796195949
p_ni:  0.203804051
Score:  0.525
Data Source:  BioPlex,STRINGDB
FGF17
Tbio
Novelty:  0.01432991
p_int:  0.795301766
p_ni:  0.204698234
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
89.1
platelet crit
1
1
1
58.4
platelet count
1
1
1
32.7
sex hormone-binding globulin measurement
1
1
1
24.5
puberty onset measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
89.1
platelet crit
1
58.4
platelet count
1
32.7
sex hormone-binding globulin measurement
1
24.5
puberty onset measurement
1
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S5
VGNC:2261
456347
Macaque
ribosomal protein S5
711259
Mouse
MGI:1097682
20103
Rat
RGD:3601
25538
Dog
ribosomal protein S5
VGNC:45737
476366
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S5
Macaque
ribosomal protein S5
Mouse
Rat
Dog
ribosomal protein S5
Publication Statistics
PubMed Score 178.89
PubMed score by year
PubTator Score 44.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title