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Tchem
RPS27
40S ribosomal protein S27

Protein Summary
Description
Component of the small ribosomal subunit (PubMed:8706699). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368567
  • ENSP00000357555
  • ENSG00000177954

Symbol
  • MPS1
  • S27
  • MPS1
  • DBA17
  • MPS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.93
transcription factor binding site profile
0.86
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.14   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.14   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (542)
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.99993326
p_ni:  0.000066738
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
p_int:  0.998691719
p_ni:  0.001308263
p_wrong:  1.8e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.995845312
p_ni:  0.004154686
p_wrong:  2e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.992834195
p_ni:  0.006925364
p_wrong:  0.000240441
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.958407044
p_ni:  0.041592956
Score:  0.15
Data Source:  BioPlex,STRINGDB
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.956962828
p_ni:  0.043037172
Data Source:  BioPlex
FUS
Tbio
Novelty:  0.00065625
p_int:  0.953949745
p_ni:  0.046050255
Score:  0.211
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.946044402
p_ni:  0.053954941
p_wrong:  6.58e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
A6NIZ1
Tdark
Family:  Enzyme
p_int:  0.897378558
p_ni:  0.063684866
p_wrong:  0.038936577
Data Source:  BioPlex
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
p_int:  0.877392862
p_ni:  0.122607133
p_wrong:  5e-9
Score:  0.909
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (66)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Axon guidance
Cap-dependent Translation Initiation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first birth measurement
2
2
2
84.9
platelet count
2
2
2
75.2
neuroimaging measurement
5
4
5
70.6
mathematical ability
2
1
2
65.2
C-reactive protein measurement
2
2
2
61.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first birth measurement
2
84.9
platelet count
2
75.2
neuroimaging measurement
5
70.6
mathematical ability
2
65.2
C-reactive protein measurement
2
61.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S27
738979
Macaque
40S ribosomal protein S27-like
100425072
Mouse
MGI:1888676
57294
Mouse
MGI:1915191
67941
Rat
RGD:621045
94266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S27
Macaque
40S ribosomal protein S27-like
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 46.14
PubMed score by year
PubTator Score 32.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title