Tbio RPS24 40S ribosomal protein S24

Protein Summary

Description

Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• P62847
• E7EPK6
• P16632
• Q5T0P7
• Q5T0P8
• Q7Z3D1

Gene Name

• RPS24

Ensembl ID

• ENST00000372360
• ENSP00000361435
• ENSG00000138326
• ENST00000440692
• ENSP00000414321
• ENST00000464716
• ENSP00000494231
• ENST00000613865
• ENSP00000478869
• ENST00000647545
• ENSP00000495212

Symbol

• S24
• DBA3
• eS24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
transcription factor binding site profile	0.85
biological process	0.79
co-expressed gene	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 40s Ribosomal Protein S24

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 40s Ribosomal Protein S24

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.31   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.31   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0