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Tbio
RPS17
40S ribosomal protein S17

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330244
  • ENSP00000346046
  • ENSG00000182774
  • ENST00000617731
  • ENSP00000483755
  • ENSG00000278229
  • ENST00000647841
  • ENSP00000498019

Symbol
  • RPS17L
  • S17
  • DBA4
  • RPS17L
  • RPS17L1
  • RPS17L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.95
gene perturbation
0.86
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.57   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.57   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (408)
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.986425132
p_ni:  0.013574868
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPSA
Tbio
Novelty:  0.00250446
p_int:  0.966775507
p_ni:  0.033224493
Score:  0.999
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.955103213
p_ni:  0.044896787
Data Source:  BioPlex
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.872235903
p_ni:  0.127764097
Score:  0.328
Data Source:  BioPlex,STRINGDB
BHLHA15
Tbio
Family:  TF
Novelty:  0.02721846
p_int:  0.845069839
p_ni:  0.154930161
Data Source:  BioPlex
RPL15
Tbio
Novelty:  0.02466708
Score:  0.999
Data Source:  STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.999
Data Source:  STRINGDB
RPS10
Tbio
Novelty:  0.01016071
Score:  0.999
Data Source:  STRINGDB
RPL39
Tbio
Novelty:  0.0307397
Score:  0.999
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
72.7
daytime rest measurement
1
1
1
72.7
self reported educational attainment
2
2
2
67.3
self reported educational attainment
2
2
2
67.3
intelligence
2
2
1
5.9
61
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
72.7
daytime rest measurement
1
72.7
self reported educational attainment
2
67.3
self reported educational attainment
2
67.3
intelligence
1
5.9
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1309526
20068
Dog
ribosomal protein S17
403681
Cow
ribosomal protein S17
VGNC:49958
788861
Pig
ribosomal protein S17
414392
Xenopus
ribosomal protein S17
XB-GENE-1016373
100145026
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
ribosomal protein S17
Cow
ribosomal protein S17
Pig
ribosomal protein S17
Xenopus
ribosomal protein S17
Publication Statistics
PubMed Score 167.57
PubMed score by year
PubTator Score 37.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title