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Tbio
RPS14
40S ribosomal protein S14

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312037
  • ENSP00000311028
  • ENSG00000164587
  • ENST00000401695
  • ENSP00000385958
  • ENST00000407193
  • ENSP00000385425
  • ENST00000521466
  • ENSP00000428509

Symbol
  • S14
  • EMTB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
transcription factor binding site profile
0.98
hub protein
0.97
disease perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.64   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.64   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (625)
PCMTD1
Tbio
Family:  Enzyme
Novelty:  0.14517534
p_int:  0.99986481
p_ni:  0.000110299
p_wrong:  0.000024891
Data Source:  BioPlex
AK6
Tbio
Family:  Kinase
Novelty:  0.173427
p_int:  0.999833308
p_ni:  0.000166692
Score:  0.979
Data Source:  BioPlex,STRINGDB
NOB1
Tbio
Novelty:  0.01209681
p_int:  0.999274442
p_ni:  0.000725558
Score:  0.994
Data Source:  BioPlex,STRINGDB
FRMD8
Tdark
Novelty:  0.39375892
p_int:  0.99902525
p_ni:  0.00097475
Score:  0.187
Data Source:  BioPlex,STRINGDB
CENPV
Tbio
Novelty:  0.00175994
p_int:  0.99574327
p_ni:  0.003104839
p_wrong:  0.001151891
Data Source:  BioPlex
TSR1
Tbio
Novelty:  0.01639069
p_int:  0.992472833
p_ni:  0.007527167
Score:  0.994
Data Source:  BioPlex,STRINGDB
RRP12
Tbio
Novelty:  0.10034381
p_int:  0.99218111
p_ni:  0.00781889
Score:  0.234
Data Source:  BioPlex,STRINGDB
ZNF430
Tdark
Family:  TF
Novelty:  3.98895047
p_int:  0.99128468
p_ni:  0.008000993
p_wrong:  0.000714327
Data Source:  BioPlex
RBM19
Tbio
Novelty:  0.15784228
p_int:  0.990142269
p_ni:  0.009857731
Data Source:  BioPlex
CCZ1B
Tdark
Novelty:  0.09724624
p_int:  0.986200368
p_ni:  0.013799632
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S14
VGNC:4153
462193
Macaque
ribosomal protein S14
710901
Mouse
MGI:98107
20044
Rat
RGD:62025
29284
Dog
ribosomal protein S14
403690
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S14
Macaque
ribosomal protein S14
Mouse
Rat
Dog
ribosomal protein S14
Publication Statistics
PubMed Score 169.64
PubMed score by year
PubTator Score 95.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title