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Tdark
RPP25L
Ribonuclease P protein subunit p25-like protein

Protein Summary
Description
May be a component of ribonuclease P or MRP. This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297613
  • ENSP00000297613
  • ENSG00000164967
  • ENST00000378959
  • ENSP00000368242

Symbol
  • C9orf23
  • C9orf23
  • bA296L22.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.8
cell type or tissue
0.78
transcription factor binding site profile
0.69
transcription factor perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
IBTK
Tbio
Family:  Enzyme
Novelty:  0.03448246
p_int:  0.999999871
p_ni:  1.9e-8
p_wrong:  1.11e-7
Data Source:  BioPlex
ENOX1
Tbio
Novelty:  0.06620772
p_int:  0.999999859
p_ni:  7.7e-8
p_wrong:  6.3e-8
Data Source:  BioPlex
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.999999254
p_ni:  7.46e-7
Score:  0.935
Data Source:  BioPlex,STRINGDB
RPP21
Tbio
Family:  Enzyme
Novelty:  0.05805689
p_int:  0.999997627
p_ni:  0.000002372
p_wrong:  1e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
CTNNAL1
Tbio
Novelty:  0.03667606
p_int:  0.999995496
p_ni:  0.000004503
p_wrong:  1e-9
Data Source:  BioPlex
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
p_int:  0.999990594
p_ni:  0.000009406
Score:  0.958
Data Source:  BioPlex,STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
p_int:  0.999986601
p_ni:  0.000013396
p_wrong:  3e-9
Score:  0.699
Data Source:  BioPlex,STRINGDB
POP7
Tbio
Family:  Enzyme
Novelty:  0.05460002
p_int:  0.999977042
p_ni:  0.000022958
Score:  0.921
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.999957167
p_ni:  0.000042832
p_wrong:  2e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.999929139
p_ni:  0.000070861
Score:  0.816
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
2
1.1
88.3
blood protein measurement
4
4
5
84.9
interleukin-11 receptor subunit alpha measurement
1
1
1
74.6
chemokine (C-C motif) ligand 27 measurement
1
1
1
70.9
adolescent idiopathic scoliosis
2
1
0
1.1
64.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
88.3
blood protein measurement
5
84.9
interleukin-11 receptor subunit alpha measurement
1
74.6
chemokine (C-C motif) ligand 27 measurement
1
70.9
adolescent idiopathic scoliosis
0
1.1
64.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P/MRP subunit p25 like
VGNC:10057
746043
Macaque
ribonuclease P/MRP subunit p25 like
700829
Mouse
MGI:1917211
69961
Rat
RGD:1306576
298002
Dog
ribonuclease P/MRP subunit p25 like
481586
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P/MRP subunit p25 like
Macaque
ribonuclease P/MRP subunit p25 like
Mouse
Rat
Dog
ribonuclease P/MRP subunit p25 like
Publication Statistics
PubMed Score 0.79
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title