Tdark RPP25L Ribonuclease P protein subunit p25-like protein

Protein Summary

Description

May be a component of ribonuclease P or MRP. This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N5L8
• D3DRM5
• RNase P protein subunit-like p25

Gene Name

• RPP25L

Ensembl ID

• ENST00000297613
• ENSP00000297613
• ENSG00000164967
• ENST00000378959
• ENSP00000368242

Symbol

• C9orf23
• C9orf23
• bA296L22.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
histone modification site profile	0.8
cell type or tissue	0.78
transcription factor binding site profile	0.69
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Ribonuclease P Protein Subunit P25-like Protein

DTO Classes

Protein / Enzyme / Nuclease / Ribonuclease P Protein Subunit P25-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.58   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.58   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (45)

Explore Interacting Targets

1 – 10 of 45

• See Interactions on String-DB

IBTK

Tbio

Family:  Enzyme

Novelty:  0.03448246

p_int:  0.999999871

p_ni:  1.9e-8

p_wrong:  1.11e-7

Data Source:  BioPlex

ENOX1

Tbio

Novelty:  0.06620772

p_int:  0.999999859

p_ni:  7.7e-8

p_wrong:  6.3e-8

Data Source:  BioPlex

RPP40

Tbio

Family:  Enzyme

Novelty:  0.05981624

p_int:  0.999999254

p_ni:  7.46e-7

Score:  0.935

Data Source:  BioPlex,STRINGDB

RPP21

Tbio

Family:  Enzyme

Novelty:  0.05805689

p_int:  0.999997627

p_ni:  0.000002372

p_wrong:  1e-9

Score:  0.857

Data Source:  BioPlex,STRINGDB

CTNNAL1

Tbio

Novelty:  0.03667606

p_int:  0.999995496

p_ni:  0.000004503

p_wrong:  1e-9

Data Source:  BioPlex

RPP38

Tbio

Family:  Enzyme

Novelty:  0.06387902

p_int:  0.999990594

p_ni:  0.000009406

Score:  0.958

Data Source:  BioPlex,STRINGDB

RPP14

Tbio

Family:  Enzyme

Novelty:  0.10813341

p_int:  0.999986601

p_ni:  0.000013396

p_wrong:  3e-9

Score:  0.699

Data Source:  BioPlex,STRINGDB

POP7

Tbio

Family:  Enzyme

Novelty:  0.05460002

p_int:  0.999977042

p_ni:  0.000022958

Score:  0.921

Data Source:  BioPlex,STRINGDB

POP4

Tbio

Family:  Enzyme

Novelty:  0.01072287

p_int:  0.999957167

p_ni:  0.000042832

p_wrong:  2e-9

Score:  0.984

Data Source:  BioPlex,STRINGDB

C18orf21

Tdark

Novelty:  0.65363998

p_int:  0.999929139

p_ni:  0.000070861

Score:  0.816

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

KEGG (2)

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5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Ribosome biogenesis in eukaryotes	77 targets	path:hsa03008
KEGG	RNA transport	157 targets	path:hsa03013

Name	Explore in Pharos	Explore in Source
Ribosome biogenesis in eukaryotes	77 targets	path:hsa03008
RNA transport	157 targets	path:hsa03013

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Functions (1)

Components (1)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (5)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chemokine (C-C motif) ligand 27 measurement	EFO_0008082	1	1	1		80.5
rheumatoid arthritis	EFO_0000685	6	2	2	1.1	69.5
adolescent idiopathic scoliosis	EFO_0005423	2	1	0	1.1	42.3
testosterone measurement	EFO_0004908	1	1	1		29
self reported educational attainment	EFO_0004784	1	1	1		7.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chemokine (C-C motif) ligand 27 measurement	EFO_0008082	1		80.5
rheumatoid arthritis	EFO_0000685	2	1.1	69.5
adolescent idiopathic scoliosis	EFO_0005423	0	1.1	42.3
testosterone measurement	EFO_0004908	1		29
self reported educational attainment	EFO_0004784	1		7.6

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UniProt Keyword Find Similar Targets

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Complete proteome
Nucleus
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
adolescent idiopathic scoliosis
chemokine (C-C motif) ligand 27 measurement
rheumatoid arthritis
self reported educational attainment
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P/MRP subunit p25 like	VGNC:10057	746043
Macaque	ribonuclease P/MRP subunit p25 like		700829
Mouse	ribonuclease P/MRP 25 subunit-like	MGI:1917211	69961
Rat	ribonuclease P/MRP subunit p25 like	RGD:1306576	298002
Dog	ribonuclease P/MRP subunit p25 like		481586

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P/MRP subunit p25 like
Macaque	ribonuclease P/MRP subunit p25 like
Mouse	ribonuclease P/MRP 25 subunit-like
Rat	ribonuclease P/MRP subunit p25 like
Dog	ribonuclease P/MRP subunit p25 like

Publication Statistics

PubMed Score 0.58

PubMed score by year

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Related Publications

Text Mined References (8)

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10

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PMID	Year	Title