Tbio RPP25 Ribonuclease P protein subunit p25

Protein Summary

Description

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA.

Uniprot Accession IDs

• Q9BUL9
• D3DW70
• Q9NX88
• RNase P protein subunit p25

Gene Name

• RPP25

Ensembl ID

• ENST00000322177
• ENSP00000317691
• ENSG00000178718

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
transcription factor binding site profile	0.9
histone modification site profile	0.8
PubMedID	0.75
tissue sample	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Ribonuclease P Protein Subunit P25

DTO Classes

Protein / Enzyme / Nuclease / Ribonuclease P Protein Subunit P25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.89   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.89   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (149)

Explore Interacting Targets

1 – 10 of 149

• See Interactions on String-DB

C18orf21

Tdark

Novelty:  0.65363998

p_int:  0.999999999

p_ni:  1e-9

Score:  0.873

Data Source:  BioPlex,STRINGDB

POP4

Tbio

Family:  Enzyme

Novelty:  0.01072287

p_int:  0.999999994

p_ni:  6e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

RPP30

Tbio

Family:  Enzyme

Novelty:  0.01375777

p_int:  0.999999762

p_ni:  2.38e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

USP13

Tchem

Family:  Enzyme

Novelty:  0.03470844

p_int:  0.999998658

p_ni:  1.5e-7

p_wrong:  0.000001192

Score:  0.248

Data Source:  BioPlex,STRINGDB

RPP21

Tbio

Family:  Enzyme

Novelty:  0.05805689

p_int:  0.999996909

p_ni:  0.000003091

Score:  0.997

Data Source:  BioPlex,STRINGDB

RPP40

Tbio

Family:  Enzyme

Novelty:  0.05981624

p_int:  0.999996217

p_ni:  0.000003783

Score:  0.998

Data Source:  BioPlex,STRINGDB

POP7

Tbio

Family:  Enzyme

Novelty:  0.05460002

p_int:  0.999994335

p_ni:  0.000005665

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPP38

Tbio

Family:  Enzyme

Novelty:  0.06387902

p_int:  0.999979439

p_ni:  0.000020561

Score:  0.998

Data Source:  BioPlex,STRINGDB

RABL2A

Tbio

Family:  Enzyme

Novelty:  0.09940618

p_int:  0.999937687

p_ni:  0.000062313

Score:  0.175

Data Source:  BioPlex,STRINGDB

RPP14

Tbio

Family:  Enzyme

Novelty:  0.10813341

p_int:  0.999875329

p_ni:  0.00012467

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (6)

KEGG (2)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
Reactome	tRNA processing	123 targets	R-HSA-72306

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
tRNA processing	123 targets	R-HSA-72306

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (2)

Components (4)

Processes (1)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ribonuclease P activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cups of coffee per day measurement	EFO_0006782	1	2	2		80.6
monocyte count	EFO_0005091	2	2	2		78.9
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		72.6
red blood cell distribution width	EFO_0005192	2	2	2		70.4
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		69.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cups of coffee per day measurement	EFO_0006782	2		80.6
monocyte count	EFO_0005091	2		78.9
mean corpuscular hemoglobin concentration	EFO_0004528	1		72.6
red blood cell distribution width	EFO_0005192	2		70.4
neutrophil percentage of leukocytes	EFO_0007990	1		69.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Hydrolase
Nucleus
Phosphoprotein
Reference proteome
RNA-binding
tRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
cups of coffee per day measurement
hypertension
low density lipoprotein cholesterol measurement
mathematical ability
mean corpuscular hemoglobin concentration
mean corpuscular volume
monocyte count
myocardial infarction
neutrophil count
neutrophil percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P and MRP subunit p25	VGNC:14730	453751
Macaque	ribonuclease P and MRP subunit p25		703796
Mouse	ribonuclease P/MRP 25 subunit	MGI:2143151	102614
Rat	ribonuclease P and MRP subunit p25	RGD:1305290	315705
Horse	ribonuclease P and MRP subunit p25	VGNC:22536	100051321

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P and MRP subunit p25
Macaque	ribonuclease P and MRP subunit p25
Mouse	ribonuclease P/MRP 25 subunit
Rat	ribonuclease P and MRP subunit p25
Horse	ribonuclease P and MRP subunit p25

Publication Statistics

PubMed Score 15.89

PubMed score by year

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PubTator Score 9.24

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (3)

Items per page:

10

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PMID	Year	Title