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Tbio
RPP25
Ribonuclease P protein subunit p25

Protein Summary
Description
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322177
  • ENSP00000317691
  • ENSG00000178718
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
transcription factor binding site profile
0.9
histone modification site profile
0.8
PubMedID
0.75
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.999999999
p_ni:  1e-9
Score:  0.873
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.999999994
p_ni:  6e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPP30
Tbio
Family:  Enzyme
Novelty:  0.01375777
p_int:  0.999999762
p_ni:  2.38e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
USP13
Tchem
Family:  Enzyme
Novelty:  0.03470844
p_int:  0.999998658
p_ni:  1.5e-7
p_wrong:  0.000001192
Score:  0.248
Data Source:  BioPlex,STRINGDB
RPP21
Tbio
Family:  Enzyme
Novelty:  0.05805689
p_int:  0.999996909
p_ni:  0.000003091
Score:  0.997
Data Source:  BioPlex,STRINGDB
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.999996217
p_ni:  0.000003783
Score:  0.998
Data Source:  BioPlex,STRINGDB
POP7
Tbio
Family:  Enzyme
Novelty:  0.05460002
p_int:  0.999994335
p_ni:  0.000005665
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
p_int:  0.999979439
p_ni:  0.000020561
Score:  0.998
Data Source:  BioPlex,STRINGDB
RABL2A
Tbio
Family:  Enzyme
Novelty:  0.09940618
p_int:  0.999937687
p_ni:  0.000062313
Score:  0.175
Data Source:  BioPlex,STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
p_int:  0.999875329
p_ni:  0.00012467
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cups of coffee per day measurement
1
2
2
90.5
3
1
0
1.2
81
monocyte count
3
2
3
69.4
neutrophil count
2
2
2
65.2
low density lipoprotein cholesterol measurement
2
2
2
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cups of coffee per day measurement
2
90.5
0
1.2
81
monocyte count
3
69.4
neutrophil count
2
65.2
low density lipoprotein cholesterol measurement
2
64
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P and MRP subunit p25
VGNC:14730
453751
Macaque
ribonuclease P and MRP subunit p25
703796
Mouse
MGI:2143151
102614
Rat
RGD:1305290
315705
Horse
ribonuclease P and MRP subunit p25
VGNC:22536
100051321
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P and MRP subunit p25
Macaque
ribonuclease P and MRP subunit p25
Mouse
Rat
Horse
ribonuclease P and MRP subunit p25
Publication Statistics
PubMed Score 19.13
PubMed score by year
PubTator Score 9.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title