RPP25
Ribonuclease P protein subunit p25
Protein Summary
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA.
- ENST00000322177
- ENSP00000317691
- ENSG00000178718
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.92 | ||
transcription factor binding site profile | 0.9 | ||
histone modification site profile | 0.8 | ||
PubMedID | 0.75 | ||
tissue sample | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.13 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.13 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (149)
C18orf21
Novelty: 0.65363998
p_int: 0.999999999
p_ni: 1e-9
Score: 0.873
Data Source: BioPlex,STRINGDB
POP4
Family: Enzyme
Novelty: 0.01072287
p_int: 0.999999994
p_ni: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
RPP30
Family: Enzyme
Novelty: 0.01375777
p_int: 0.999999762
p_ni: 2.38e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
USP13
Family: Enzyme
Novelty: 0.03470844
p_int: 0.999998658
p_ni: 1.5e-7
p_wrong: 0.000001192
Score: 0.248
Data Source: BioPlex,STRINGDB
RPP21
Family: Enzyme
Novelty: 0.05805689
p_int: 0.999996909
p_ni: 0.000003091
Score: 0.997
Data Source: BioPlex,STRINGDB
RPP40
Family: Enzyme
Novelty: 0.05981624
p_int: 0.999996217
p_ni: 0.000003783
Score: 0.998
Data Source: BioPlex,STRINGDB
POP7
Family: Enzyme
Novelty: 0.05460002
p_int: 0.999994335
p_ni: 0.000005665
Score: 0.999
Data Source: BioPlex,STRINGDB
RPP38
Family: Enzyme
Novelty: 0.06387902
p_int: 0.999979439
p_ni: 0.000020561
Score: 0.998
Data Source: BioPlex,STRINGDB
RABL2A
Family: Enzyme
Novelty: 0.09940618
p_int: 0.999937687
p_ni: 0.000062313
Score: 0.175
Data Source: BioPlex,STRINGDB
RPP14
Family: Enzyme
Novelty: 0.10813341
p_int: 0.999875329
p_ni: 0.00012467
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (6)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Reactome | Metabolism of RNA | ||||
Reactome | rRNA processing | ||||
Reactome | rRNA processing in the nucleus and cytosol | ||||
Reactome | tRNA processing | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Metabolism of RNA | ||||
rRNA processing | ||||
rRNA processing in the nucleus and cytosol | ||||
tRNA processing | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations (null)
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cups of coffee per day measurement | 1 | 2 | 2 | 90.5 | |||||
3 | 1 | 0 | 1.2 | 81 | |||||
monocyte count | 3 | 2 | 3 | 69.4 | |||||
neutrophil count | 2 | 2 | 2 | 65.2 | |||||
low density lipoprotein cholesterol measurement | 2 | 2 | 2 | 64 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cups of coffee per day measurement | 2 | 90.5 | |||||
0 | 1.2 | 81 | |||||
monocyte count | 3 | 69.4 | |||||
neutrophil count | 2 | 65.2 | |||||
low density lipoprotein cholesterol measurement | 2 | 64 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ribonuclease P and MRP subunit p25 | VGNC:14730 | 453751 | |||||
Macaque | ribonuclease P and MRP subunit p25 | 703796 | ||||||
Mouse | MGI:2143151 | 102614 | ||||||
Rat | RGD:1305290 | 315705 | ||||||
Horse | ribonuclease P and MRP subunit p25 | VGNC:22536 | 100051321 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ribonuclease P and MRP subunit p25 | |||||
Macaque | ribonuclease P and MRP subunit p25 | |||||
Mouse | ||||||
Rat | ||||||
Horse | ribonuclease P and MRP subunit p25 | |||||
Publication Statistics
PubMed Score 19.13
PubMed score by year
PubTator Score 9.24
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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