Tbio RPP21 Ribonuclease P protein subunit p21

Protein Summary

Description

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

Uniprot Accession IDs

• Q9H633
• A2AAZ8
• B0S834
• B0S835
• Q5JPL9
• Q5JPM1
• Q5STF8
• Q5STF9
• Q5STG2
• Q5SU41
• Q5SU42
• Q86Y49
• Q86Y50
• Q86Y51
• Q96F16
• RNaseP protein p21

Gene Name

• RPP21

Ensembl ID

• ENST00000376642
• ENSP00000365829
• ENSG00000239927
• ENST00000411784
• ENSP00000412619
• ENSG00000241863
• ENST00000414187
• ENSP00000398396
• ENSG00000243009
• ENST00000415583
• ENSP00000403747
• ENST00000416977
• ENSP00000404312
• ENSG00000241779
• ENST00000424616
• ENSP00000399295
• ENST00000425575
• ENSP00000405834
• ENST00000428040
• ENSP00000394320
• ENSG00000241370
• ENST00000430900
• ENSP00000415046
• ENST00000433076
• ENSP00000409799
• ENST00000434282
• ENSP00000414284
• ENSG00000242726
• ENST00000435318
• ENSP00000411003
• ENSG00000239865
• ENST00000436442
• ENSP00000397778
• ENST00000437470
• ENSP00000408610
• ENST00000442966
• ENSP00000403833
• ENST00000455025
• ENSP00000409193

Symbol

• C6orf135
• CAT60
• CAT60
• C6orf135

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.66
tissue sample	0.62
molecular function	0.56
disease	0.53
tissue	0.51

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Ribonuclease P Protein Subunit P21

Protein / Hydrolase / Ribonuclease P Protein Subunit P21

DTO Classes

Protein / Enzyme / Hydrolase / Ribonuclease P Protein Subunit P21

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.76   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.76   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0