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Tbio
RPP14
Ribonuclease P protein subunit p14

Protein Summary
Description
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295959
  • ENSP00000295959
  • ENSG00000163684
  • ENST00000445193
  • ENSP00000412894
  • ENST00000466547
  • ENSP00000419909

Symbol
  • P14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor binding site profile
0.89
virus perturbation
0.83
kinase perturbation
0.81
cell type or tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0