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Tbio
RPLP1
60S acidic ribosomal protein P1

Protein Summary
Description
Plays an important role in the elongation step of protein synthesis. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode differen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260379
  • ENSP00000346037
  • ENSG00000137818
  • ENST00000357790
  • ENSP00000350437

Symbol
  • RRP1
  • P1
  • LP1
  • RPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
microRNA
1
small molecule perturbation
1
ligand (protein) perturbation
0.96
hub protein
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.68   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.68   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (357)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.986319347
p_ni:  0.013680652
Score:  0.505
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.895331147
p_ni:  0.104668851
p_wrong:  2e-9
Score:  0.422
Data Source:  BioPlex,STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.999
Data Source:  STRINGDB
RPL27A
Tbio
Novelty:  0.03424762
Score:  0.999
Data Source:  STRINGDB
RPL31
Tbio
Novelty:  0.03427872
Score:  0.999
Data Source:  STRINGDB
RPS10
Tbio
Novelty:  0.01016071
Score:  0.999
Data Source:  STRINGDB
RPL17
Tbio
Novelty:  0.02730924
Score:  0.999
Data Source:  STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
Score:  0.999
Data Source:  STRINGDB
RPS4X
Tbio
Novelty:  0.01396038
Score:  0.999
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
68.8
diastolic blood pressure
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
68.8
diastolic blood pressure
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein lateral stalk subunit P1
695442
Macaque
ribosomal protein, large, P1-like
713991
Mouse
MGI:1927099
56040
Rat
RGD:621774
140661
Horse
ribosomal protein lateral stalk subunit P1
100052525
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein lateral stalk subunit P1
Macaque
ribosomal protein, large, P1-like
Mouse
Rat
Horse
ribosomal protein lateral stalk subunit P1
Publication Statistics
PubMed Score 75.68
PubMed score by year
PubTator Score 132.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title