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Tbio
RPL8
60S ribosomal protein L8

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262584
  • ENSP00000262584
  • ENSG00000161016
  • ENST00000394920
  • ENSP00000378378
  • ENST00000528957
  • ENSP00000433464

Symbol
  • L8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.99
protein domain
0.99
microRNA
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (600)
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.998054454
p_ni:  0.001945546
Score:  0.665
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.997999187
p_ni:  0.002000813
Score:  0.999
Data Source:  BioPlex,STRINGDB
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.993111572
p_ni:  0.006888428
Score:  0.186
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.987052934
p_ni:  0.012947066
Score:  0.549
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.976304685
p_ni:  0.023695315
Score:  0.566
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.975103156
p_ni:  0.024896844
Score:  0.555
Data Source:  BioPlex,STRINGDB
RPL7L1
Tdark
Novelty:  0.78428937
p_int:  0.974419301
p_ni:  0.025580699
Score:  0.939
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.968195872
p_ni:  0.031804128
Score:  0.759
Data Source:  BioPlex,STRINGDB
GLYR1
Tbio
Family:  Epigenetic
Novelty:  0.036121
p_int:  0.964211397
p_ni:  0.035788603
Score:  0.561
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.950966328
p_ni:  0.049033672
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
1
0
10.3
76.8
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
0
10.3
76.8
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L8
VGNC:803
464473
Macaque
ribosomal protein L8
708535
Mouse
MGI:1350927
26961
Dog
ribosomal protein L8
VGNC:45720
475130
Horse
ribosomal protein L8 [Source:HGNC Symbol;Acc:HGNC:10368]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L8
Macaque
ribosomal protein L8
Mouse
Dog
ribosomal protein L8
Horse
ribosomal protein L8 [Source:HGNC Symbol;Acc:HGNC:10368]
Publication Statistics
PubMed Score 90.76
PubMed score by year
PubTator Score 12.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title