RPL37
60S ribosomal protein L37
Protein Summary
Binds to the 23S rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
- ENST00000274242
- ENSP00000274242
- ENSG00000145592
- L37
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 1 | ||
disease perturbation | 0.96 | ||
transcription factor binding site profile | 0.94 | ||
cell type or tissue | 0.78 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.05 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 126 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.05 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 126 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (395)
MRPL51
Novelty: 0.24304433
p_int: 0.999621037
p_ni: 0.000378961
p_wrong: 2e-9
Data Source: BioPlex
H2AFX
Novelty: 0.00048694
p_int: 0.999104556
p_ni: 0.000874823
p_wrong: 0.000020621
Data Source: BioPlex
MRPL16
Novelty: 0.38562971
p_int: 0.998386255
p_ni: 0.001613745
Score: 0.354
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (34)
Reactome (32)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Eukaryotic Translation Elongation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
Developmental Biology | ||||
Disease | ||||
Eukaryotic Translation Elongation | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 3 | 0 | 1.3 | 92.2 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 54.4 | |||||
1 | 1 | 0 | 1.2 | 52 | |||||
reticulocyte measurement | 1 | 1 | 1 | 47.7 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 92.2 | |||||
mean corpuscular hemoglobin concentration | 1 | 54.4 | |||||
0 | 1.2 | 52 | |||||
reticulocyte measurement | 1 | 47.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ribosomal protein L37 | 695667 | ||||||
Mouse | MGI:1914531 | 67281 | ||||||
Dog | 60S ribosomal protein L37 [Source:RefSeq peptide;Acc:NP_001239158] | |||||||
Horse | ribosomal protein L37 | 100066211 | ||||||
Cow | ribosomal protein L37 | 768317 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ribosomal protein L37 | |||||
Mouse | ||||||
Dog | 60S ribosomal protein L37 [Source:RefSeq peptide;Acc:NP_001239158] | |||||
Horse | ribosomal protein L37 | |||||
Cow | ribosomal protein L37 | |||||
Publication Statistics
PubMed Score 23.05
PubMed score by year
PubTator Score 19.38
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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