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Tbio
RPL31
60S ribosomal protein L31

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264258
  • ENSP00000264258
  • ENSG00000071082
  • ENST00000409028
  • ENSP00000386717
  • ENST00000409320
  • ENSP00000387163
  • ENST00000409733
  • ENSP00000386681

Symbol
  • L31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
transcription factor perturbation
0.96
virus perturbation
0.96
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (463)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.909730305
p_ni:  0.090269695
Score:  0.551
Data Source:  BioPlex,STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
p_int:  0.840355964
p_ni:  0.159644036
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS7
Tbio
Novelty:  0.00745987
Score:  0.999
Data Source:  STRINGDB
RPL19
Tbio
Novelty:  0.00756385
Score:  0.999
Data Source:  STRINGDB
RPL27
Tbio
Novelty:  0.0157566
Score:  0.999
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.999
Data Source:  STRINGDB
RPS15A
Tbio
Novelty:  0.03502821
Score:  0.999
Data Source:  STRINGDB
RPL23
Tbio
Novelty:  0.02741113
Score:  0.999
Data Source:  STRINGDB
RPL21
Tbio
Novelty:  0.01023355
Score:  0.999
Data Source:  STRINGDB
RPL10L
Tbio
Novelty:  0.22224997
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
80.7
intraocular pressure measurement
3
3
3
70.1
myeloid white cell count
1
1
1
68.8
leukocyte count
2
2
2
67.7
educational attainment
1
2
2
65.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
80.7
intraocular pressure measurement
3
70.1
myeloid white cell count
1
68.8
leukocyte count
2
67.7
educational attainment
2
65.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
60S ribosomal protein L31
744983
Macaque
ribosomal protein L31
710744
Mouse
MGI:2149632
114641
Rat
RGD:621202
64298
Rat
Species
Name
OMA
EggNOG
Inparanoid
Chimp
60S ribosomal protein L31
Macaque
ribosomal protein L31
Mouse
Rat
Rat
Publication Statistics
PubMed Score 30.75
PubMed score by year
PubTator Score 31.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title