Tbio RPL28 60S ribosomal protein L28

Protein Summary

Description

Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P46779
• B2R4A6
• B4DEP9
• C9JB50
• E9PB24
• G5E9L2
• Q6IAY0
• Q96FX1
• Q9BWQ0

Gene Name

• RPL28

Ensembl ID

• ENST00000344063
• ENSP00000342787
• ENSG00000108107
• ENST00000428193
• ENSP00000391665
• ENST00000431533
• ENSP00000400596
• ENST00000558815
• ENSP00000452909
• ENST00000559463
• ENSP00000453319
• ENST00000560583
• ENSP00000453029

Symbol

• L28

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.99
kinase perturbation	0.99
transcription factor binding site profile	0.9
gene perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60s Ribosomal Protein L28

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60s Ribosomal Protein L28

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0