Tbio RPL27 60S ribosomal protein L27

Protein Summary

Description

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L27e family of ribosomal proteins and a component of the 60S subunit. A splice site mutation in this gene has been identified in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• P61353
• P08526
• Q4G0A9

Gene Name

• RPL27

Ensembl ID

• ENST00000253788
• ENSP00000253788
• ENSG00000131469
• ENST00000589037
• ENSP00000467587
• ENST00000589913
• ENSP00000464813

Symbol

• L27
• DBA16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
small molecule perturbation	1
kinase perturbation	0.99
transcription factor binding site profile	0.98

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60s Ribosomal Protein L27

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60s Ribosomal Protein L27

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (446)

Explore Interacting Targets

1 – 10 of 446

• See Interactions on String-DB

CNBP

Tbio

Novelty:  0.00404247

p_int:  0.987708095

p_ni:  0.012291905

Score:  0.62

Data Source:  BioPlex,STRINGDB

RPL30

Tbio

Novelty:  0.0134194

p_int:  0.961247098

p_ni:  0.038752902

Score:  0.999

Data Source:  BioPlex,STRINGDB

PUM3

Tbio

Novelty:  0.02344206

p_int:  0.881925799

p_ni:  0.118074201

Score:  0.652

Data Source:  BioPlex,STRINGDB

H1FOO

Tbio

Novelty:  0.02189067

p_int:  0.878429954

p_ni:  0.121570046

Data Source:  BioPlex

RPL28

Tbio

Novelty:  0.03136035

p_int:  0.858120168

p_ni:  0.141879832

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPL37A

Tbio

Novelty:  0.03475061

p_int:  0.855228233

p_ni:  0.144771767

Score:  0.999

Data Source:  BioPlex,STRINGDB

RRS1

Tbio

Novelty:  0.01643671

p_int:  0.813829025

p_ni:  0.186170975

Score:  0.697

Data Source:  BioPlex,STRINGDB

MECP2

Tchem

Family:  TF

Novelty:  0.00051767

p_int:  0.811781078

p_ni:  0.188218922

Data Source:  BioPlex

SART3

Tbio

Novelty:  0.02353492

p_int:  0.788847422

p_ni:  0.211152578

Data Source:  BioPlex

KNOP1

Tdark

Novelty:  0.5609503

p_int:  0.775245896

p_ni:  0.224754104

Score:  0.534

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (34)

Reactome (32)

KEGG (1)

WikiPathways (1)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685
Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (2)

Components (9)

Processes (5)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural constituent of ribosome	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	2	2		87.8
myeloid white cell count	EFO_0007988	1	1	1		71.9
aspartate aminotransferase measurement	EFO_0004736	1	1	0	7.1	55.2
leukocyte count	EFO_0004308	1	1	1		55.2
age at menopause	EFO_0004704	1	1	1		45.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		87.8
myeloid white cell count	EFO_0007988	1		71.9
aspartate aminotransferase measurement	EFO_0004736	0	7.1	55.2
leukocyte count	EFO_0004308	1		55.2
age at menopause	EFO_0004704	1		45.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Diamond-Blackfan anemia
Direct protein sequencing
Endoplasmic reticulum
Reference proteome
Ribonucleoprotein
Ribosomal protein

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
age at menopause
aspartate aminotransferase measurement
body mass index
leukocyte count
lymphocyte percentage of leukocytes
monocyte percentage of leukocytes
myeloid white cell count
neutrophil count
neutrophil percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribosomal protein L27	VGNC:9575	454706
Macaque	ribosomal protein L27		712352
Mouse	ribosomal protein L27	MGI:98036	19942
Rat	ribosomal protein L27	RGD:621192	64306
Dog	ribosomal protein L27		403688

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribosomal protein L27
Macaque	ribosomal protein L27
Mouse	ribosomal protein L27
Rat	ribosomal protein L27
Dog	ribosomal protein L27

Publication Statistics

PubMed Score 55.00

PubMed score by year

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PubTator Score 37.79

PubTator score by year

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Related Publications

Text Mined References (31)

GeneRif Annotations (2)

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10

0 of 0

PMID	Year	Title