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Tbio
RPL26
60S ribosomal protein L26

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293842
  • ENSP00000293842
  • ENSG00000161970
  • ENST00000582556
  • ENSP00000463470
  • ENST00000583011
  • ENSP00000462322
  • ENST00000584164
  • ENSP00000463784
  • ENST00000648839
  • ENSP00000498177

Symbol
  • L26
  • DBA11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.95
transcription factor binding site profile
0.95
gene perturbation
0.88
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.92   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.92   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (481)
E4F1
Tbio
Family:  TF
Novelty:  0.02192338
p_int:  0.987811947
p_ni:  0.012188053
Data Source:  BioPlex
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.883572279
p_ni:  0.116427721
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS8
Tbio
Novelty:  0.00976281
p_int:  0.805845155
p_ni:  0.194154845
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.799897819
p_ni:  0.200102181
Score:  0.536
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.795012565
p_ni:  0.204987435
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL7
Tbio
Novelty:  0.00552644
p_int:  0.773184645
p_ni:  0.226815355
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.750710424
p_ni:  0.249289576
Score:  0.235
Data Source:  BioPlex,STRINGDB
RPS15A
Tbio
Novelty:  0.03502821
Score:  0.999
Data Source:  STRINGDB
RPS10
Tbio
Novelty:  0.01016071
Score:  0.999
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
81.9
total cholesterol measurement
2
2
2
77.4
hemoglobin measurement
1
1
1
72.9
mean corpuscular hemoglobin concentration
2
2
2
58.2
reticulocyte measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
81.9
total cholesterol measurement
2
77.4
hemoglobin measurement
1
72.9
mean corpuscular hemoglobin concentration
2
58.2
reticulocyte measurement
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L26
746392
Macaque
ribosomal protein L26
717378
Mouse
MGI:106022
19941
Dog
ribosomal protein L26
479496
Horse
ribosomal protein L26
100062602
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L26
Macaque
ribosomal protein L26
Mouse
Dog
ribosomal protein L26
Horse
ribosomal protein L26
Publication Statistics
PubMed Score 40.92
PubMed score by year
PubTator Score 75.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title