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Tbio
RPL14
60S ribosomal protein L14

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338970
  • ENSP00000345156
  • ENSG00000188846
  • ENST00000396203
  • ENSP00000379506

Symbol
  • L14
  • RL14
  • hRL14
  • CTG-B33
  • CAG-ISL-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
virus perturbation
0.99
co-expressed gene
0.87
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (466)
TRAF4
Tbio
Novelty:  0.01317133
p_int:  0.999994022
p_ni:  0.000005966
p_wrong:  1.2e-8
Data Source:  BioPlex
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.999217667
p_ni:  0.000782333
Score:  0.366
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.998489864
p_ni:  0.001510135
Score:  0.997
Data Source:  BioPlex,STRINGDB
BUD13
Tbio
Novelty:  0.05228416
p_int:  0.998487543
p_ni:  0.001512457
Score:  0.555
Data Source:  BioPlex,STRINGDB
ZCCHC7
Tbio
Novelty:  0.01655453
p_int:  0.998298554
p_ni:  0.001701446
Score:  0.171
Data Source:  BioPlex,STRINGDB
ARGLU1
Tdark
Novelty:  0.28840832
p_int:  0.995202413
p_ni:  0.000213267
p_wrong:  0.00458432
Score:  0.515
Data Source:  BioPlex,STRINGDB
ZBTB24
Tbio
Family:  TF
Novelty:  0.041401
p_int:  0.993872479
p_ni:  0.00612751
p_wrong:  1.1e-8
Score:  0.286
Data Source:  BioPlex,STRINGDB
ZFP62
Tdark
Family:  TF
Novelty:  0.17608098
p_int:  0.990372498
p_ni:  0.009627502
Score:  0.378
Data Source:  BioPlex,STRINGDB
TAF1D
Tdark
Family:  Enzyme
Novelty:  0.26072519
p_int:  0.989951634
p_ni:  0.009982918
p_wrong:  0.000065447
Score:  0.517
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.981334432
p_ni:  0.018665568
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
33.1
1
1
0
1.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
33.1
0
1.1
17.8
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L14
VGNC:2542
735578
Mouse
MGI:1914365
67115
Rat
RGD:621180
65043
Dog
ribosomal protein L14
477031
Horse
ribosomal protein L14
VGNC:22523
100067962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L14
Mouse
Rat
Dog
ribosomal protein L14
Horse
ribosomal protein L14
Publication Statistics
PubMed Score 61.07
PubMed score by year
PubTator Score 20.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title