RPL13
60S ribosomal protein L13
Protein Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011]
- ENST00000311528
- ENSP00000307889
- ENSG00000167526
- ENST00000393099
- ENSP00000376811
- ENST00000452368
- ENSP00000438959
- ENST00000567815
- ENSP00000455009
- BBC1
- L13
- BBC1
- D16S44E
- D16S444E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
transcription factor perturbation | 1 | ||
hub protein | 0.99 | ||
kinase perturbation | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.16 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 132 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.16 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 132 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (478)
TUBA8
Novelty: 0.06454549
p_int: 0.999999791
p_ni: 2.09e-7
Score: 0.34
Data Source: BioPlex,STRINGDB
NSUN4
Family: Enzyme
Novelty: 0.15593771
p_int: 0.994421013
p_ni: 0.005578031
p_wrong: 9.56e-7
Score: 0.39
Data Source: BioPlex,STRINGDB
MRPL30
Novelty: 1.03623556
p_int: 0.991133123
p_ni: 0.008845893
p_wrong: 0.000020984
Score: 0.281
Data Source: BioPlex,STRINGDB
CNBP
Novelty: 0.00404247
p_int: 0.957317148
p_ni: 0.042682852
Score: 0.397
Data Source: BioPlex,STRINGDB
MRPL28
Novelty: 0.23845162
p_int: 0.921047217
p_ni: 0.078952783
Score: 0.665
Data Source: BioPlex,STRINGDB
MRPL38
Novelty: 0.71587283
p_int: 0.920492748
p_ni: 0.079507252
Score: 0.569
Data Source: BioPlex,STRINGDB
MRPL27
Novelty: 0.15636105
p_int: 0.913717733
p_ni: 0.086282267
Score: 0.545
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (34)
Reactome (32)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Eukaryotic Translation Elongation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
Developmental Biology | ||||
Disease | ||||
Eukaryotic Translation Elongation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
suntan | 1 | 4 | 4 | 98.9 | |||||
hair color | 1 | 2 | 0 | 6.4 | 92.9 | ||||
homocysteine measurement | 2 | 2 | 2 | 92.3 | |||||
glomerular filtration rate | 5 | 4 | 5 | 92 | |||||
1 | 1 | 1 | 86 | ||||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
suntan | 4 | 98.9 | |||||
hair color | 0 | 6.4 | 92.9 | ||||
homocysteine measurement | 2 | 92.3 | |||||
glomerular filtration rate | 5 | 92 | |||||
1 | 86 | ||||||
Find similar targets by:
IDG Resources
Orthologs (18)
1 – 5 of 18
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ribosomal protein L13 | VGNC:5912 | 454316 | |||||
Macaque | ribosomal protein L13 | 700603 | ||||||
Mouse | MGI:105922 | 270106 | ||||||
Rat | RGD:621179 | 81765 | ||||||
Dog | ribosomal protein L13 | VGNC:53438 | 479612 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ribosomal protein L13 | |||||
Macaque | ribosomal protein L13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ribosomal protein L13 | |||||
Publication Statistics
PubMed Score 58.16
PubMed score by year
PubTator Score 29.05
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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