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Tbio
RPH3AL
Rab effector Noc2

Protein Summary
Description
Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323434
  • ENSP00000319210
  • ENSG00000181031
  • ENST00000331302
  • ENSP00000328977
  • ENST00000536489
  • ENSP00000438224
  • ENST00000608278
  • ENSP00000483035
  • ENSG00000262334
  • ENST00000608519
  • ENSP00000476394
  • ENST00000618002
  • ENSP00000479485
  • ENST00000632000
  • ENSP00000487689
  • ENST00000632545
  • ENSP00000487851
  • ENST00000632616
  • ENSP00000487649

Symbol
  • NOC2
  • NOC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
hub protein
0.75
transcription factor perturbation
0.68
biological process
0.64
cellular component
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.8   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.8   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0