You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RPH3A
Rabphilin-3A

Protein Summary
Description
Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). The protein encoded by this gene is thought to be an effector for RAB3A, which is a small G protein that acts in the late stages of neurotransmitter exocytosis. The encoded protein may be involved in neurotransmitter release and synaptic vesicle traffic. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389385
  • ENSP00000374036
  • ENSG00000089169
  • ENST00000415485
  • ENSP00000405357
  • ENST00000543106
  • ENSP00000440384
  • ENST00000551052
  • ENSP00000448297

Symbol
  • KIAA0985
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.92
cellular component
0.76
trait
0.75
gene perturbation
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.38   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.38   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
MPP5
Tbio
Novelty:  0.01707773
p_int:  0.999999901
p_ni:  9.8e-8
p_wrong:  1e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
DOC2B
Tbio
Novelty:  0.05460532
p_int:  0.999999048
p_ni:  3.6e-8
p_wrong:  9.16e-7
Score:  0.37
Data Source:  BioPlex,STRINGDB
RAB8B
Tbio
Family:  Enzyme
Novelty:  0.06230082
p_int:  0.999822499
p_ni:  0.000177499
p_wrong:  2e-9
Score:  0.566
Data Source:  BioPlex,STRINGDB
TP63
Tbio
Family:  TF
Novelty:  0.00336108
p_int:  0.999772796
p_ni:  0.000227203
Score:  0.243
Data Source:  BioPlex,STRINGDB
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
p_int:  0.999415761
p_wrong:  0.000584238
Score:  0.963
Data Source:  BioPlex,STRINGDB
ALOX15B
Tchem
Family:  Enzyme
Novelty:  0.01578108
p_int:  0.998054085
p_ni:  0.001924213
p_wrong:  0.000021702
Score:  0.209
Data Source:  BioPlex,STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
p_int:  0.992442008
p_ni:  0.007557987
p_wrong:  5e-9
Score:  0.796
Data Source:  BioPlex,STRINGDB
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.960245121
p_ni:  0.03974568
p_wrong:  0.000009199
Score:  0.167
Data Source:  BioPlex,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.993
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
3
3
86.3
serum gamma-glutamyl transferase measurement
1
1
1
83.2
high density lipoprotein cholesterol measurement
1
2
0
1.3
69.6
alcohol consumption measurement
1
1
0
1.6
66.3
alcohol drinking
1
1
0
1.6
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
86.3
serum gamma-glutamyl transferase measurement
1
83.2
high density lipoprotein cholesterol measurement
0
1.3
69.6
alcohol consumption measurement
0
1.6
66.3
alcohol drinking
0
1.6
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rabphilin 3A
VGNC:5575
738818
Macaque
rabphilin 3A
712197
Mouse
MGI:102788
19894
Rat
RGD:620073
171039
Dog
rabphilin 3A
VGNC:45713
611038
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rabphilin 3A
Macaque
rabphilin 3A
Mouse
Rat
Dog
rabphilin 3A
Publication Statistics
PubMed Score 85.38
PubMed score by year
PubTator Score 36.47
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title