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Tbio
RPGRIP1L
Protein fantom

Protein Summary
Description
Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (PubMed:19464661). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity). The protein encoded by this gene can localize to the basal body-centrosome complex or to primary cilia and centrosomes in ciliated cells. The encoded protein has been found to interact with nephrocystin-4. Defects in this gene are a cause o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262135
  • ENSP00000262135
  • ENSG00000103494
  • ENST00000379925
  • ENSP00000369257
  • ENST00000647211
  • ENSP00000493946

Symbol
  • FTM
  • KIAA1005
  • NPHP8
  • FTM
  • MKS5
  • CORS3
  • JBTS7
  • NPHP8
  • PPP1R134
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
microRNA
0.76
phenotype
0.73
cell line
0.62
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.59   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.59   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (194)
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
p_int:  1
Score:  0.969
Data Source:  BioPlex,STRINGDB
THEG
Tdark
Novelty:  0.09923649
p_int:  0.99996665
p_ni:  0.000032087
p_wrong:  0.000001263
Data Source:  BioPlex
ZSCAN29
Tdark
Family:  TF
Novelty:  1.70466621
p_int:  0.999867877
p_ni:  0.000132119
p_wrong:  4e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.999
Data Source:  Reactome,STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.994
Data Source:  STRINGDB
NPHP1
Tbio
Novelty:  0.01113034
Score:  0.993
Data Source:  Reactome,STRINGDB
TMEM67
Tbio
Novelty:  0.02573267
Score:  0.992
Data Source:  STRINGDB
CC2D2A
Tbio
Novelty:  0.03684487
Score:  0.991
Data Source:  STRINGDB
AHI1
Tbio
Novelty:  0.01180688
Score:  0.99
Data Source:  STRINGDB
TMEM216
Tbio
Novelty:  0.07870718
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Hedgehog 'off' state
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Hedgehog 'off' state
Organelle biogenesis and maintenance
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (111)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
47
30
90
5.3
100
type 2 diabetes mellitus
18
9
6
1.1
99.9
body weight
4
5
3
6.3
99.8
waist-hip ratio
5
5
7
99.6
body fat percentage
7
5
14
99.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
90
5.3
100
type 2 diabetes mellitus
6
1.1
99.9
body weight
3
6.3
99.8
waist-hip ratio
7
99.6
body fat percentage
14
99.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RPGRIP1 like
VGNC:10368
454089
Macaque
RPGRIP1 like
697345
Mouse
MGI:1920563
244585
Rat
RGD:1311099
307724
Dog
RPGRIP1 like
VGNC:45712
487278
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RPGRIP1 like
Macaque
RPGRIP1 like
Mouse
Rat
Dog
RPGRIP1 like
Publication Statistics
PubMed Score 172.59
PubMed score by year
PubTator Score 37.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title