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Tbio
RPGR
X-linked retinitis pigmentosa GTPase regulator

Protein Summary
Description
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia. This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have bee ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318842
  • ENSP00000322219
  • ENSG00000156313
  • ENST00000339363
  • ENSP00000343671
  • ENST00000378505
  • ENSP00000367766
  • ENST00000474584
  • ENSP00000418926
  • ENST00000482855
  • ENSP00000419276
  • ENST00000642395
  • ENSP00000493468
  • ENST00000644337
  • ENSP00000494557
  • ENST00000645032
  • ENSP00000495537

Symbol
  • RP3
  • XLRP3
  • CRD
  • RP3
  • COD1
  • PCDX
  • RP15
  • XLRP3
  • orf15
  • CORDX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.86
histone modification site profile
0.76
biological term
0.7
small molecule perturbation
0.64
phenotype
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 473.11   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 473.11   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0